Integrated structural model of the palladin-actin complex using XL-MS, docking, NMR, and SAXS.

Unlabelled: Palladin is an actin binding protein that accelerates actin polymerization and is linked to metastasis of several types of cancer. Previously, three lysine residues in an immunoglobulin-like domain of palladin have been identified as essential for actin binding. However, it is still unknown where palladin binds to F-actin.