Publications by authors named "Colborn K"
Article Synopsis
- Around 5-10% of pancreatic cancer patients don't express CA 19-9, and it's unclear how this affects their cancer severity and prognosis.
- A study analyzed data from 88,749 pancreatic cancer patients, finding that non-expressors had a higher chance of distant metastasis and a shorter median overall survival compared to those with normal CA 19-9 levels.
- The findings suggest that patients who are non-expressors of CA 19-9 might need different diagnostic approaches and more aggressive treatment strategies.
Background: We assessed the impact of breast cancer (BC) patients receiving their own patient-reported outcome (PRO) results on future PROs.
Methods: Newly diagnosed female BC patients completed validated measures of satisfaction with breasts (SB), and psychosocial (PsyW), physical (PhW), and sexual wellbeing (SW) longitudinally during treatment. Patients were randomized to receive their PRO scores (Intervention) or not (Control).
Objective: Improvement of surgical care is dependent upon evidence-based practices (EBPs), policies, procedures, and innovations. The objective of this study was to understand and synthesize the use of implementation science (IS) in surgical care.
Summary Background Data: This article summarizes the existing literature to identify the frequency and types of EBPs selected for surgical care, IS frameworks that guided the published research, and prominent facilitators and barriers.
Background: It is unclear how patient-reported outcomes (PROs) change longitudinally after breast cancer surgery. We sought to compare trends in PROs among patients who underwent lumpectomy versus mastectomy over the first year after surgery.
Patients And Methods: Newly diagnosed stage 0-III female patients with breast cancer who underwent lumpectomy or mastectomy at an academic breast center between June 2019 and March 2023 were invited to participate in a longitudinal PRO study.
Article Synopsis
- The study investigates the impact of preoperative chemo(radio)therapy on patients with localized pancreatic adenocarcinoma, focusing on the rare occurrence of pathological complete response (pCR), where no cancer cells are found post-surgery.
- Conducted in 19 centers across 8 countries with 1758 participants, the research shows that only 4.8% of patients achieved pCR, which is linked to better overall survival rates compared to those who did not achieve pCR.
- Factors influencing the likelihood of pCR included the use of multiagent chemotherapy regimens other than the (m)FOLFIRINOX treatment, highlighting the need for tailored therapeutic approaches.
Article Synopsis
- Data sharing is becoming a big part of health research, especially with new rules from the National Institutes of Health in 2023 that include qualitative studies, which look at people's experiences and opinions.
- The Palliative Care Research Cooperative Group (PCRC) created a new data repository for qualitative research to go along with their existing quantitative data, working with the Qualitative Data Repository (QDR).
- They developed guidelines and reached out to researchers to help them share their data, while also learning important lessons during the process to improve future data sharing practices.
Background: Adjuvant therapy is associated with improved pancreatic cancer survival after neoadjuvant chemotherapy and surgery. However, whether adjuvant treatment should include radiotherapy is unclear in this setting.
Methods: This study queried the National Cancer Database for pancreatic adenocarcinoma patients who underwent curative resection after multiagent neoadjuvant chemotherapy between 2010 and 2019 and received adjuvant treatment.
Background: In 2012, the American Society of Anesthesiologists (ASA) published guidelines recommending against routine preoperative laboratory testing for low-risk patients to reduce unnecessary medical expenditures. The aim of this study was to assess the change in routine preoperative laboratory testing in low-risk versus higher-risk patients before and after release of these guidelines.
Methods: The ACS-NSQIP database, 2005-2018, was separated into low-risk versus higher-risk patients based upon a previously published stratification.
Objective: The COVID-19 pandemic has drastically altered the medical landscape. Various strategies have been employed to preserve hospital beds, personal protective equipment, and other resources to accommodate the surges of COVID-19 positive patients, hospital overcapacities, and staffing shortages. This has had a dramatic effect on vascular surgical practice.
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- Surgical diagnostic lung biopsy (DLB) is important for managing pulmonary diseases, but its safety in critically ill patients is not well established. This study aimed to see if a patient's pre-surgery condition affects complication rates post-DLB.
- Data from 285 patients showed those coming from the ICU had the highest rates of 30-day mortality and complications, with ICU patients having a significantly greater risk of negative outcomes compared to outpatients.
- The findings suggest that critically ill patients undergoing DLB are at greater risk for serious complications and death within 30 days, indicating the need for careful consideration before this procedure in such vulnerable populations.
Patient-reported outcomes (PROs) are an underreported aspect of surgical recovery. The purpose of our study was to track PROs after robotic anatomic lung to determine the timing to recovery of baseline patient baseline quality of life. This was a prospective cohort study at an academic medical center (4/2021-12/2022).
View Article and Find Full Text PDFObjective: Inadvertent perioperative hypothermia has been associated with poor surgical outcomes. The purpose of this study was to evaluate the incidence and associated postoperative complications of inadvertent perioperative hypothermia in patients undergoing robotic-assisted thoracic surgery lung resections.
Methods: This was a single-center, retrospective cohort study evaluating all consecutive patients who underwent robotic-assisted thoracic surgery lung resection between January 1, 2021, and November 30, 2022.
Context: Scientific journals are the primary source for dissemination of research findings, and this process relies on rigorous editorial and peer-review. As part of continuing efforts by the Journal of Pain and Symptom Management (JPSM) to advance equity, diversity, and inclusion, JPSM's leadership requested an external evaluation of their publication decisions.
Objectives: 1) Describe primary author characteristics associated with final decisions to accept or reject manuscripts submitted for publication; 2) Report on whether there are potential publication biases in the JPSM editorial or peer-review processes.
Objective: The purpose of this study was to determine if an association between Social Vulnerability Index (SVI) and risk-adjusted complications exists in a broad spectrum of surgical patients.
Summary Background Data: Growing evidence supports the impact of social circumstances on surgical outcomes. SVI is a neighborhood-based measure accounting for sociodemographic factors putting communities at risk.
Objective: To estimate preoperative risk of postoperative infections using structured electronic health record (EHR) data.
Background: Surveillance and reporting of postoperative infections is primarily done through costly, labor-intensive manual chart reviews on a small sample of patients. Automated methods using statistical models applied to postoperative EHR data have shown promise to augment manual review as they can cover all operations in a timely manner.
Background: Patient reported outcome measures (PROMs) are important for patient-centered, value-based care; however, implementation into surgical practice remains limited. We aimed to demonstrate feasibility of measuring PROMs in an academic breast cancer clinic.
Methods: We conducted a pilot study implementing the patient-reported outcome measure BREAST-Q among patients with Stage 0-III breast cancer at a single institution from 06/2019-03/2023 using the Reach, Effectiveness, Adoption, Implementation, and Maintenance (RE-AIM) framework.
Article Synopsis
- Disadvantaged families often face significant barriers in getting timely referrals and diagnoses for autism spectrum disorder (ASD) in their young children, leading to delays in receiving necessary services.
- Trained autism family navigators (AFNs) worked with these families to identify and address barriers, providing support through activities like care coordination and education.
- The study highlighted that many mothers, particularly Latinx and Spanish-speaking, encountered multiple challenges including systemic issues like incomplete screenings and inadequate referrals, underscoring the need for improved healthcare navigation.
Background: There are persistent racial and ethnic health disparities in end-of-life health outcomes in the United States. African American patients are less likely than White patients to access palliative care, enroll in hospice care, have documented goals of care discussions with their healthcare providers, receive adequate symptom control, or die at home. We developed Community Health Worker Intervention for Disparities in Palliative Care (DeCIDE PC) to address these disparities.
View Article and Find Full Text PDFBackground: Outcomes for patients undergoing emergency thoracic operations have not been well described. This study was designed to compare postoperative outcomes among patients undergoing emergency versus nonemergency thoracic operations.
Methods: We retrospectively analyzed the American College of Surgeons National Surgical Quality Improvement Program database (2005-2018).
Background: The gold standard for detecting postoperative complications uses databases like the American College of Surgeons National Surgical Quality Improvement Program, a multi-centered database based on manual chart review. However, their limitations and costs have led many centers to discontinue participation. Novel techniques to detect postoperative complications must be developed and implemented with surgeon involvement, which is paramount to their adoption.
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- A study examined the outcomes of patients with isolated lung metastases after surgery for pancreatic ductal adenocarcinoma, hypothesizing that pulmonary metastasectomy could enhance survival with minimal risks.
- Analyzing data from 39 patients, the researchers found that those who had pulmonary metastasectomy lived significantly longer after their recurrence (30.8 months) compared to those who didn't (18.6 months).
- While overall survival rates were similar between groups, patients undergoing the procedure had higher survival rates at 3 years post-diagnosis (100% vs 64%) and 2 years post-recurrence (79% vs 32%), with only minor complications and no related deaths.
Background: To measure the impact of the COVID-19 pandemic on the management of patients with carotid artery stenosis.
Methods: We prospectively collected data from 25 centers (19 centers in the United States and 6 centers internationally) on postponed carotid artery operations between March 2020 and January 2022. We describe the characteristics of these patients and their planned operations, along with outcomes including mortality and neurological deterioration during the period of operative delay due to the COVID-19 pandemic.
Background: Infectious disease exposures in early life are increasingly recognized as a risk factor for poor subsequent growth and neurodevelopment. We aimed to evaluate the association between cumulative illness with neurodevelopment and growth outcomes in a birth cohort of Guatemalan infants.
Methods: From June 2017 to July 2018, infants 0-3 months of age living in a resource-limited region of rural southwest Guatemala were enrolled and underwent weekly at-home surveillance for caregiver-reported cough, fever, and vomiting/diarrhea.
Background: Completion axillary lymph node dissection (cALND) was standard treatment for breast cancer with positive sentinel lymph nodes (SLNs) until 2011, when data from the Z11 and AMAROS trials challenged its survival benefit in early stage breast cancer. We assessed the contribution of patient, tumor, and facility factors on cALND use in patients undergoing mastectomy and SLN biopsy.
Patients And Methods: Using the National Cancer Database, patients diagnosed from 2012 to 2017 who underwent upfront mastectomy and SLN biopsy with at least one positive SLN were included.
Background: Thirty-day mortality after outpatient surgery is unexpected and undesired. We investigated preoperative risk factors, operative variables, and postoperative complications associated with 30-day death after outpatient surgery.
Methods: Using the 2005 to 2018 American College of Surgeons National Surgical Quality Improvement Program database, we evaluated 30-day mortality rate trends over time after outpatient operations.