Mutual Effects of Single and Combined CFTR Modulators and Bacterial Infection in Cystic Fibrosis.

Cystic fibrosis transmembrane conductance regulator (CFTR) modulators improve clinical outcomes with varied efficacies in patients with CF. However, the mutual effects of CFTR modulators and bacterial adaptation, together with antibiotic regimens, can influence clinical outcomes. We evaluated the effects of ivacaftor (IVA), lumacaftor (LUM), tezacaftor, elexacaftor, and a three-modulator combination of elexacaftor, tezacaftor, and ivacaftor (ETI), alone or combined with antibiotics, on sequential CF isolates.

Primary syphilis of the rectum--endoscopic and clinical features. Report of a case.

A 33-year-old man was admitted to our hospital for suspected rectal tumor. Endoscopy showed a rectal mass not typical of carcinoma, and histologic evaluation of biopsy specimens revealed granulomatous inflammation. Venereal Disease Research Laboratories (VDRL) and Treponema pallidum hemagglutination (TPHA) tests became positive during hospitalization, and dark-field examination was positive for Treponemas, thus allowing the diagnosis of chancre of the rectum.

[Detection of left intraventricular thromboses. Comparison of 2-dimensional ultrasonics with scanography and scintigraphy with indium 111-labeled platelets].

Three methods of diagnostic imaging : bi-dimensional ultrasonography, scanography and 111Indium-labelled platelet scintigraphy were compared in 61 patients to detect left intraventricular thrombotic lesions, in order to determine their respective diagnostic values.