Publications by authors named "Colaluca J"
Effect of somatostatin analogs on gastric acid secretion in dogs and rats.
Int J Pept Protein Res
September 1990
Article Synopsis
- The study examined how superactive analogs of somatostatin impact gastric acid secretion in conscious dogs and rats.
- Two specific analogs, RC-160 and RC-121, were found to be 4-5 times more effective than the standard somatostatin-14 in reducing gastric acid response to stimulants.
- The research suggests these analogs could have significant clinical applications for controlling gastric acid secretion.
The effects of administration of (pyro)Glu-His-Gly-OH and its analogs on food consumption and 2-Deoxy-D-Glucose (2-DG)-induced gastric acid secretion were examined in rats. (Pyro)Glu-His-Gly-OH and (pyro)Glu-His-EA significantly reduced food consumption, but not gastric acid secretion as compared with controls. The tripeptides: (pyro)Glu-3Me-His-Gly-OH, (pyro)Glu-His-D-Ala-OH, and (pyro)Glu-Phe-Gly-OH were found to significantly inhibit 2-DG-induced gastric acid secretion.
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