Landscape drives zoonotic malaria prevalence in non-human primates.

Zoonotic disease dynamics in wildlife hosts are rarely quantified at macroecological scales due to the lack of systematic surveys. Non-human primates (NHPs) host a zoonotic malaria of public health concern and the main barrier to malaria elimination in Southeast Asia. Understanding of regional infection dynamics in wildlife is limited.

RshA mutations contributing to tigecycline resistance in .

Tigecycline is an important rescue antibiotic for many bacterial infections. In , tigecycline resistance has been associated with dysregulated stress response caused by aberrations in the interaction of the SigH and RshA factors. In this study, two tigecycline-resistant mutants of (CL5A and CL6A) with mutations in the gene were studied using gene complementation, RT-qPCR and the bacterial adenylate cyclase two-hybrid (BACTH) system.

A stop-gain mutation in sigma factor SigH (MAB_3543c) may be associated with tigecycline resistance in .

Tigecycline is currently acknowledged to be one of the most effective antibiotics against infections caused by . The genetic determinants of tigecycline resistance in are not well understood. In this study, we characterized a tigecycline-resistant mutant, designated CL7, to identify the potential resistance mechanism.