Cortical thickness in obsessive-compulsive disorder: multisite mega-analysis of 780 brain scans from six centres.

Background: There is accumulating evidence for the role of fronto-striatal and associated circuits in obsessive-compulsive disorder (OCD) but limited and conflicting data on alterations in cortical thickness.

Aims: To investigate alterations in cortical thickness and subcortical volume in OCD.

Method: In total, 412 patients with OCD and 368 healthy adults underwent magnetic resonance imaging scans.

Altered executive control network resting-state connectivity in social anxiety disorder.

Objectives: Research into the neural basis of social anxiety disorder (SAD) suggests alterations in prefrontal networks, which may in turn disrupt regulation of the limbic system. Better understanding of the disturbed interface between these networks may improve current pathogenic models of this disorder.

Methods: Applying group independent component analysis (ICA) to recordings of fMRI resting-state, connectivity in the executive control network was studied in 18 patients with SAD and 15 age- and sex-matched healthy controls.