Back to the Future: From Appendage Development Toward Future Human Hair Follicle Neogenesis.

Hair disorders such as alopecia and hirsutism often impact the social and psychological well-being of an individual. This also holds true for patients with severe burns who have lost their hair follicles (HFs). HFs stimulate proper wound healing and prevent scar formation; thus, HF research can benefit numerous patients.

Isolation, expansion and neural differentiation of stem cells from human plucked hair: a further step towards autologous nerve recovery.

Stem cells from the adult hair follicle bulge can differentiate into neurons and glia, which is advantageous for the development of an autologous cell-based therapy for neurological diseases. Consequently, bulge stem cells from plucked hair may increase opportunities for personalized neuroregenerative therapy. Hairs were plucked from the scalps of healthy donors, and the bulges were cultured without prior tissue treatment.

Advances in hair transplantation: longitudinal partial follicular unit transplantation.

There are different techniques of hair transplantation. The most common and known hair transplantation methods are the 'strip' method, where a strip of skin containing hair follicles is removed, cut into grafts and implanted in the recipient area, and the follicle unit extraction (FUE) method, in which whole follicle units are extracted one by one and implanted one by one back into the recipient area. The FUE method is more patient friendly and leaves only tiny scars compared to the strip method, which leaves visible linear scars at the donor area.

The influence of preservation solution on the viability of grafts in hair transplantation surgery.

Hair transplantation techniques have changed in the last decades. Partial longitudinal follicular unit transplantation is a new hair transplantation technique, which differs from all other hair transplantation techniques by the size of the graft and therefore much more vulnerable grafts compared to the conventional hair transplantation grafts. In this study, we reveal the influence of the preservation solution on the viability of the grafts.

[Therapeutic options for androgenetic alopecia].

Androgenetic alopecia (AGA) is the most common type of hair loss. There are different treatment possibilities for the prevention of and as a remedy for AGA. The broad spectrum of possibilities varies from doing nothing to hair transplantation.

Improved hair restoration method for burns.

Background: Extracted partial longitudinal follicular units can be used as complete follicular units to regenerate completely differentiated hair growth. The partial follicular units that remained in the dermis in the donor area can survive and produce hairs. This technique enables us to multiply hair follicles in vivo, while preserving the donor area and therefore is suitable in persons, who have a relative small donor area compared to the recipient area, as in scalp burns.

Donor hair follicle preservation by partial follicular unit extraction. A method to optimize hair transplantation.

Background: There are different stem cell pools located in the hair follicle.

Objective: To try to determine whether follicular units can survive a partial extraction and whether this partial extracted follicular unit can regenerate new hairs.

Methods: From five individuals, between 100 and 150 grafts were harvested from the occipital area of the scalp.