Publications by authors named "Coen D A Stehouwer"

Article Synopsis
  • The study examines how socioeconomic position (SEP), food environments, walkability, and greenspace impact type 2 diabetes (T2D) risk, focusing on their interconnection.
  • Lower SEP correlates with a higher risk of T2D, with significant hazard ratios indicating a strong link between education, income, occupation, and diabetes prevalence.
  • Environmental factors only weakly mediate the relationship between SEP and T2D, suggesting that while lower SEP leads to a less healthy environment, this isn't the primary driver for increased diabetes risk.
View Article and Find Full Text PDF

Objective: Type D (Distressed) personality combines negative affectivity (NA) and social inhibition (SI) and is associated with an increased risk of cardiometabolic diseases. Here, we examined the association of Type D traits with 230 (predominantly) lipid metabolites and metabolite ratios.

Methods: Four Dutch cohorts were included, comprising 10,834 individuals.

View Article and Find Full Text PDF

Objectives: This study aimed to examine the relationship between measures of kidney function and impaired lung function in individuals with diabetes and to assess all-cause mortality risk associated with having chronic kidney disease (CKD) and or impaired lung function.

Design: Cross-sectional and retrospective cohort study.

Setting: The National Health and Nutrition Examination Survey 2007-2012.

View Article and Find Full Text PDF
Article Synopsis
  • This study examined the link between plasma biomarkers indicating endothelial dysfunction and cognitive performance in a sample of 9,414 older adults from the Netherlands, aged 57 to 93 years.
  • Researchers created a composite score from three specific biomarkers and assessed various cognitive functions like executive function and memory.
  • Results indicated a small, consistent association between higher endothelial dysfunction scores and poorer cognitive performance, but no evidence suggested that these markers influenced cognitive decline over time.
View Article and Find Full Text PDF

Low socioeconomic position (SEP) has been identified as a risk factor for type 2 diabetes mellitus (T2DM), and psychosocial resources might be on the pathway in this association. We examined two poor psychosocial resources, low control beliefs and inferiority beliefs, that might link low SEP with T2DM. 8292 participants aged 40-75 living in Southern Netherlands participated in The Maastricht Study starting from September 2010 to October 2020 and were followed up to 10 years with annual questionnaires.

View Article and Find Full Text PDF

Background: Epidemiological and toxicological studies indicate that increased exposure to air pollutants can lead to neurodegenerative diseases. To further confirm this relationship, we evaluated the association between exposure to ambient air pollutants and corneal nerve measures as a surrogate for neurodegeneration, using corneal confocal microscopy.

Methods: We used population-based observational cross-sectional data from The Maastricht Study including N = 3635 participants (mean age 59.

View Article and Find Full Text PDF

Background: Socioeconomic inequalities in cognitive impairment may partly act through structural brain damage and reduced connectivity. This study investigated the extent to which the association of early-life socioeconomic position (SEP) with later-life cognitive functioning is mediated by later-life SEP, and whether the associations of SEP with later-life cognitive functioning can be explained by structural brain damage and connectivity.

Methods: We used cross-sectional data from the Dutch population-based Maastricht Study (n = 4,839; mean age 59.

View Article and Find Full Text PDF
Article Synopsis
  • The study investigates how fructose 1-phosphate (F1P) influences the process of de novo lipogenesis (DNL) in the liver, specifically focusing on two regulators: glucokinase regulatory protein (GKRP) and carbohydrate response element binding protein (ChREBP).
  • Aldolase B deficient mice, which show increased F1P levels and DNL, were used to assess the effects of manipulating GKRP and ChREBP on lipid synthesis.
  • Results indicated that while knocking out GKRP reduced palmitate synthesis, knocking down ChREBP normalized enzyme expression involved in DNL, highlighting their roles in regulating liver fat accumulation, despite no change in triglyceride levels.
View Article and Find Full Text PDF

Aim: To investigate the effect of dipeptidyl peptidase-4 inhibitors (DPP4-Is) and glucagon-like peptide-1 receptor agonists (GLP1-RAs) on diabetic foot ulcer (DFU) and DFU-related outcomes (lower limb amputation [LLA], DFU-related hospitalization and mortality).

Methods: We performed a cohort study with data from the Clinical Practice Research Datalink Aurum database with linkage to hospital data. We included people with type 2 diabetes starting treatment with metformin.

View Article and Find Full Text PDF

Background: Overweight and obesity impose a considerable individual and social burden, and the urban environments might encompass factors that contribute to obesity. Nevertheless, there is a scarcity of research that takes into account the simultaneous interaction of multiple environmental factors.

Objectives: Our objective was to perform an exposome-wide association study of body mass index (BMI) in a multicohort setting of 15 studies.

View Article and Find Full Text PDF
Article Synopsis
  • - The study investigates how life-course exposure to risk and protective factors affects brain structure and cognition, using data from The Maastricht Study of 4,881 middle-aged individuals.
  • - Brain-age gap (BAG) is calculated by comparing individuals' actual age to their predicted brain age based on neuroimaging, with a larger BAG indicating accelerated brain aging and poorer cognitive function.
  • - Results indicate that higher dementia risk, measured by a lifestyle score, is linked to a greater BAG and reduced cognitive abilities, emphasizing the importance of lifestyle factors on brain health.
View Article and Find Full Text PDF

Background: Cerebral microvascular dysfunction may contribute to depression via disruption of brain structures involved in mood regulation, but evidence is limited. We investigated the association of retinal microvascular function, a proxy for microvascular function in the brain, with incidence and trajectories of clinically relevant depressive symptoms.

Methods: Longitudinal data are from The Maastricht Study of 5952 participants (59.

View Article and Find Full Text PDF

Introduction/aims: Nerve conduction studies (NCSs) are widely used to support the clinical diagnosis of neuromuscular disorders. The aims of this study were to obtain reference values for peroneal, tibial, and sural NCSs and to examine the associations with demographic and anthropometric factors.

Methods: In 5099 participants (aged 40-79 years) without type 2 diabetes of The Maastricht Study, NCSs of peroneal, tibial, and sural nerves were performed.

View Article and Find Full Text PDF

In population-based cohort studies, magnetic resonance imaging (MRI) is vital for examining brain structure and function. Advanced MRI techniques, such as diffusion-weighted MRI (dMRI) and resting-state functional MRI (rs-fMRI), provide insights into brain connectivity. However, biases in MRI data acquisition and processing can impact brain connectivity measures and their associations with demographic and clinical variables.

View Article and Find Full Text PDF

Background: Microvascular dysfunction is involved in the development of various cerebral disorders. It may contribute to these disorders by disrupting white matter tracts and altering brain connectivity, but evidence is scarce. We investigated the association between multiple biomarkers of microvascular function and whole-brain white matter connectivity.

View Article and Find Full Text PDF

Aims/hypothesis: Type 2 diabetes is a highly heterogeneous disease for which new subgroups ('clusters') have been proposed based on disease severity: moderate age-related diabetes (MARD), moderate obesity-related diabetes (MOD), severe insulin-deficient diabetes (SIDD) and severe insulin-resistant diabetes (SIRD). It is unknown how disease severity is reflected in terms of quality of life in these clusters. Therefore, we aimed to investigate the cluster characteristics and cluster-wise evolution of quality of life in the previously defined clusters of type 2 diabetes.

View Article and Find Full Text PDF

Background: Type 2 diabetes mellitus (T2DM) is a common chronic disease that disproportionally affects disadvantaged groups. People with a low socioeconomic position (SEP) have increased risk of T2DM and people with a low SEP and T2DM have higher HbA-levels compared to people with T2DM and high SEP. The aim of this study is to analyze longitudinal socioeconomic differences in health-related functioning in people with T2DM.

View Article and Find Full Text PDF
Article Synopsis
  • High cognitive activity may help reduce the risk of cognitive decline and dementia, as suggested by the study.
  • The research examined the relationship between an individual's need to engage in cognitively stimulating activities (NFC) and brain health among 4209 participants, revealing that those with higher NFC scores had better cognitive functioning and lower odds of cognitive impairment and small vessel disease.
  • The findings indicate that having a strong motivation for cognitive engagement can positively impact cognitive abilities, especially in middle-aged individuals, though no significant links were found between NFC and certain brain structure measures.
View Article and Find Full Text PDF

Background: Observational studies have identified an inverse association between education and non-alcoholic fatty liver disease (NAFLD). However, it is not possible to establish causality for this relationship.

Aims: To gain more insight into the causal nature of the relationship between education and NAFLD.

View Article and Find Full Text PDF

Purpose: Bariatric surgery is regarded as a valuable treatment option for adolescents with severe obesity. However, high-quality evidence of its superiority over prolonged conservative treatment with multidisciplinary lifestyle intervention (MLI) is limited. This study investigated the efficacy and safety of bariatric surgery in adolescents without sufficient weight loss after MLI for severe obesity.

View Article and Find Full Text PDF

Fatigue and insomnia, potentially induced by inflammation, are distressing symptoms experienced by colorectal cancer (CRC) survivors. Emerging evidence suggests that besides the nutritional quality and quantity, also the timing, frequency and regularity of dietary intake (chrono-nutrition) could be important for alleviating these symptoms. We investigated longitudinal associations of circadian eating patterns with sleep quality, fatigue and inflammation in CRC survivors.

View Article and Find Full Text PDF

Background: Late-life depression has been associated with volume changes of the hippocampus. However, little is known about its association with specific hippocampal subfields over time.

Aims: We investigated whether hippocampal subfield volumes were associated with prevalence, course and incidence of depressive symptoms.

View Article and Find Full Text PDF

Background And Aims: Physical activity (PA) constitutes an established protective factor while sedentary behavior (SB) an emerging independent risk factor for cardiovascular diseases. This study evaluated the association of PA and SB with endothelial dysfunction (ED) depending on kidney function status.

Methods: Cross-sectional data from the prospective, population-based Maastricht Study were used.

View Article and Find Full Text PDF

Cardiometabolic disease is a major threat to global health. Precision medicine has great potential to help to reduce the burden of this common and complex disease cluster, and to enhance contemporary evidence-based medicine. Its key pillars are diagnostics; prediction (of the primary disease); prevention (of the primary disease); prognosis (prediction of complications of the primary disease); treatment (of the primary disease or its complications); and monitoring (of risk exposure, treatment response, and disease progression or remission).

View Article and Find Full Text PDF