Does Mental Fatigue Affect Physical Performance in Wheelchair Basketball Players? An Individualized Cognitive Load Approach.

The negative effects of mental fatigue on physical performance have been well established in different sports that require aerobic endurance, but, in this study, we investigated the impact of mental fatigue on the physical performance of paralympic (wheelchair basketball) athletes. Eleven participants completed a baseline and two experimental sessions, each separated by 24 hours. The baseline session familiarized participants with the measurements.

Hidden Encephalopathy: A Mysterious Case.

Hepatic encephalopathy (HE) is a complex neurological disorder characterized by a wide range of neuropsychiatric abnormalities, from subtle cognitive deficits to deep coma. While cirrhosis is the most common underlying condition, HE can also occur in other conditions. The pathogenesis of HE is multifactorial, but a key factor is the liver's impaired capacity to detoxify substances absorbed from the gut, notably ammonia.

[Translated article] Functional evaluation after cortical button fixation for distal biceps ruptures - Is there any difference between manual or non-manual workers?

Background This study aims to compare clinical and functional results after distal biceps tendon repair in manual workers vs. non-manual workers. Methods This is a retrospective comparative study which refers to 57 cases with distal biceps tendon rupture, divided in manual workers (24 elbows) and non-manual workers (33), that were treated by a single incision with cortical button and interference screw fixation.

A newly bat-borne hantavirus detected in Seba's short-tailed bats (Carollia perspicillata) in the Brazilian Atlantic Rainforest.

Background: Bat-borne hantaviruses have been identified worldwide but little is known about neotropical bats in the megadiverse biomes of the American continent. Although serological evidence has hinted at hantavirus circulation in Brazil, the scarce number of genomic detection represents a gap to understand viral diversity, prevalence, and ecology of bat-borne hantaviruses.

Objective: We aim to investigate and evaluate the presence and prevalence of bat-borne hantavirus in the Brazilian Atlantic Forest.

Genetic diversity of Bartonella spp. in vampire bats and associated Streblidae bat flies in the Brazilian Amazon.

Among mammals, bats stand out as important reservoirs for Bartonella spp., second only to rodents. In Brazil, out of the 182 species of bats described, three are hematophagous: Desmodus rotundus, Diphylla ecaudata and Diaemus youngii.

Effects of eplontersen on symptoms of autonomic neuropathy in hereditary transthyretin-mediated amyloidosis: secondary analysis from the NEURO-TTRansform trial.

Background: The NEURO-TTRansform trial showed that after 66 weeks of treatment, eplontersen significantly reduced neuropathic impairment and improved quality of life (QoL) in patients with hereditary transthyretin-mediated amyloidosis with polyneuropathy (ATTRv-PN). In this secondary analysis from NEURO-TTRansform, autonomic impairment, and the impact of eplontersen on autonomic impairment progression was evaluated through 85 weeks in patients randomised to eplontersen ( = 144) versus external placebo ( = 60; through Week 66 from the NEURO-TTR trial).

Methods: Change from baseline in modified Neuropathy Impairment Score +7 (mNIS+7) composite score, Norfolk Quality of Life-Diabetic Neuropathy (Norfolk QoL-DN) total score, and the Neuropathy Symptoms and Change (NSC) total score was evaluated.

First description of a mobatvirus (Hantaviridae) in the Amazon region.

From 1988-2023, Pará accounted for the highest proportion of deforestation among all states in the Brazilian Amazon. Specifically, 57.20 % of the territory in the Santa Bárbara municipality was deforested as of 2023.

A study of professional practices, attitudes and barriers to blended tube feeding in Australia and New Zealand.

Aims: This study investigates the utilisation of blended tube feeding by health professionals in Australia and New Zealand, assessing factors influencing its implementation following the Australasian Society of Parenteral and Enteral Nutrition blended tube feeding consensus statement.

Methods: A cross-sectional survey was conducted targeting health professionals across Australia and New Zealand. The survey comprised 35-questions including multiple choice, Likert scales and open-ended responses, to gain insights into blended tube feeding practices and perspectives.

Functional evaluation after cortical button fixation for distal biceps ruptures - Is there any difference between manual or non-manual workers?

Background: This study aims to compare clinical and functional results after distal biceps tendon repair in manual workers vs. non-manual workers.

Methods: This is a retrospective comparative study which refers to 57 cases with distal biceps tendon rupture, divided in manual workers (24 elbows) and non-manual workers (33), that were treated by a single incision with cortical button and interference screw fixation.

The Impact of Heavy Metal Contamination in Humans and Periodontitis: A Scoping Review.

Periodontal disease, one of the most prevalent diseases worldwide, is a chronic inflammatory disease caused by dysbiotic dental biofilms that trigger the host's immune response. Periodontitis is a type of periodontal disease characterized by the destruction of tissues that support the teeth. The disease is influenced by various systemic and environmental risk factors.

Brain MRI in patients with V30M hereditary transthyretin amyloidosis.

Background: Central nervous system dysfunction is common in longstanding hereditary transthyretin amyloidosis (ATTRv) caused by the V30M (p.V50M) mutation. Neuropathology studies show leptomeningeal amyloid deposition and cerebral amyloid angiopathy (CAA).

Investigating the Chemical Profile of Underexplored Parts of (Baru) Using the PS-MS Technique.

The baru ( Vog.), a fruit native to the Cerrado biome, is well-known for its almonds, which are extensively exploited and exported. Unfortunately, the remaining parts of this fruit are often discarded.

Diversity of spp., spp. and spp. in vampire bats.

Although bats (Mammalia: Chiroptera) act as natural reservoirs for many zoonotic pathogens around the world, few studies have investigated the occurrence of agents in bats, especially vampire bats. The family (order Rickettsiales) encompasses obligate intracellular bacteria of the genera , , , , , and . The present study aimed to investigate, using molecular techniques, the presence of species of , , and in vampire bats sampled in northern Brazil.

Hereditary transthyretin amyloidosis: a myriad of factors that influence phenotypic variability.

Hereditary transthyretin-related amyloidosis (ATTRv amyloidosis) is a rare and progressively debilitating disease characterized by the deposition of transthyretin (TTR) amyloid fibrils in various organs and tissues, most commonly in the heart and peripheral nerves. This pathological deposition can lead to significant organ dysfunction and, ultimately, organ failure. ATTRv amyloidosis exhibits a broad range of clinical presentations, from purely neurological symptoms to purely cardiac manifestations, as well as mixed phenotypes which result from both neurological and cardiac implications.

Usefulness of minimally invasive autopsy in the diagnosis of arboviruses to increase the sensitivity of the Epidemiological Surveillance System in Ceará, Brazil.

Objective: To create a protocol for performing minimally invasive autopsies (MIA) in detecting deaths from arboviruses and report preliminary data from its application in Ceará state, Brazil.

Methods: Training was provided to medical pathologists on MIA.

Results: A protocol was established for performing MIA, defining criteria for sample collection, storage methods, and diagnoses to be carried out according to the type of biological sample; 43 MIAs were performed in three months.

Physical function as a marker to assess the effects of occupational long-term pesticide exposure.

In this cross-sectional study, we determined the relative impact of long-term occupational exposure to pesticides on physical performance and perception of tiredness. Experimental data was collected in locus from agricultural communities and included surveys to assess the duration of exposure to pesticides, social status, habitual physical activity levels, presence of common mental disorders (CMD), and self-reported tiredness. Plasmatic cholinesterase (PChE), body composition and traditional functional performance tests (Handgrip strength-HGS; Time up and go-TUG; and Sit-to-stand-STS) were obtained.

Heterogeneity in families with ATTRV30M amyloidosis: a historical and longitudinal Portuguese case study impact for genetic counselling.

Background: Hereditary transthyretin amyloidosis (ATTRv amyloidosis) is an inherited disease, where the study of family history holds importance. This study evaluates the changes of age-of-onset (AOO) and other age-related clinical factors within and among families affected by ATTRv amyloidosis.

Methods: We analysed information from 934 trees, focusing on family, parents, probands and siblings relationships.

Evaluation of deprescription by general practitioners in elderly people with different levels of dependence: cross-sectional study.

Background: Polypharmacy is easily achieved in elderly patients with multimorbidity and it is associated with a higher risk of potentially inappropriate medication use and worse health outcomes. Studies have shown that deprescription is safe, however, some barriers have been identified. The aim of this study was to analyse Portuguese General Practitioners (GP) deprescription's attitudes using clinical vignettes.