The noradrenergic and cholinergic modulation of functionally distinct regions of the brain has become one of the primary organizational principles behind understanding the contribution of each system to the diversity of neural computation in the central nervous system. Decades of work has shown that a diverse family of receptors, stratified across different brain regions, and circuit-specific afferent and efferent projections play a critical role in helping such widespread neuromodulatory systems obtain substantial heterogeneity in neural information processing. This review briefly discusses the anatomical layout of both the noradrenergic and cholinergic systems, as well as the types and distributions of relevant receptors for each system.
View Article and Find Full Text PDFAlzheimer's disease (AD) poses a significant global health concern over the next several decades. Multiple hypotheses have been put forth that attempt to explain the underlying pathophysiology of AD. Many of these are briefly reviewed here, but to-date no disease-altering therapy has been achieved.
View Article and Find Full Text PDFThe sleep-wake and circadian cycles are influenced by light, particularly in the short-wavelength portion of the visible spectrum. Most personal light-emitting electronic devices are enriched in this so-called "blue" light. Exposure to these devices in the evening can disturb sleep.
View Article and Find Full Text PDFDocumentation burden has become an increasing concern as the prevalence of electronic health records (EHRs) has grown. The implementation of a new EHR is an opportunity to measure and improve documentation burden, as well as assess the role of the EHR in clinician workflow. Time-motion observation is the preferred method for evaluating workflow.
View Article and Find Full Text PDF