Publications by authors named "Cody R Appa"
Article Synopsis
- Bacteria from the genus Chlamydia are harmful to both humans and animals, causing diseases like pneumonia and infections in the genital and ocular regions.
- These bacteria are obligate intracellular parasites that rely on a complex life cycle involving different stages: the elementary body (EB) for infection, the reticulate body (RB) for replication, and the intermediate body (IB) for transition between these forms.
- A study showed that high levels of the regulatory protein Euo can halt the bacteria's developmental cycle at the IB stage, affecting their ability to mature into the infectious EB form, but this pause can be reversed by lowering Euo levels.
The human pathogen Chlamydia trachomatis proceeds through a multi phenotypic developmental cycle with each cell form specialized for different roles in pathogenesis. Understanding the mechanisms regulating this complex cycle has historically been hampered by limited genetic tools. In an effort to address this issue, we developed a translational control system to regulate gene expression in Chlamydia using a synthetic riboswitch.
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