Publications by authors named "Cody McIntire"
Article Synopsis
- A Phase II clinical trial examined the effects of intravenous vitamin C on patients receiving hematopoietic stem cell transplants to reduce nonrelapse mortality (NRM).
- Patients (55 total) were given IV vitamin C for 14 days, which corrected their initial vitamin C deficiency and showed a trend towards lower NRM (11%) compared to historical controls (25%).
- The study suggests that vitamin C repletion is safe and may improve survival rates (82% vs. 62%), but further randomized trials are necessary to validate these findings.
Unlabelled: Intravenous (IV) vitamin C improves organ function and reduces inflammation in sepsis, an inflammatory state like the post-hematopoietic stem cell transplant (HCT) milieu. The safety and efficacy of parenteral vitamin C after allogeneic HCT were evaluated in a phase I/II trial. Clinical outcomes were compared with a propensity score - matched historical control.
View Article and Find Full Text PDFUnlabelled: Intravenous (IV) vitamin C improves organ function and reduces inflammation in sepsis, an inflammatory state like the post-hematopoietic stem cell transplant (SCT) milieu. The safety and efficacy of parenteral vitamin C after allogeneic hematopoietic stem cell transplant (HSCT) were evaluated in a phase I/II trial and clinical outcomes compared with a propensity score - matched historical control.
Methods: Patients with advanced hematologic malignancies were enrolled in a phase 2 clinical trial, receiving IV vitamin C, 50mg/kg/d, divided into 3 doses given on days 1-14 after HSCT, followed by 500 mg bid oral from day 15 until 6 months post-SCT.