Publications by authors named "Cody Machen"
The cornea is exposed daily to a number of mechanical stresses including shear stress from tear film and blinking. Over time, these stressors can lead to changes in the extracellular matrix that alter corneal stiffness, cell-substrate structures, and the integrity of cell-cell junctions. We hypothesized that changes in tissue stiffness of the cornea with age may alter calcium signaling between cells after injury, and the downstream effects of this signaling on cellular motility and wound healing.
View Article and Find Full Text PDFWnt signaling regulates cell fate decisions in diverse contexts during development, and loss of Wnt signaling in the cranial mesenchyme results in a robust and binary cell fate switch from cranial bone to ectopic cartilage. The Extracellular signal-regulated protein kinase 1 and 2 (ERK1/2) and Wnt signaling pathways are activated during calvarial osteoblast cell fate selection. Here, we test the hypothesis that ERK signaling is a mediator of Wnt-dependent cell fate decisions in the cranial mesenchyme.
View Article and Find Full Text PDFArticle Synopsis
- - New research reveals that acute myocardial infarction (AMI) heightens inflammation and MMP-9 activity in the kidney, underscoring a need for better understanding of this response.
- - A study involving swine showed that using Impella support before heart reperfusion decreased MMP-9 levels and reduced kidney damage compared to ischemia-reperfusion or VA-ECMO methods.
- - Impella support not only lessened heart injury but also mitigated harmful kidney signaling pathways, suggesting it may offer protective benefits during cardiac events like AMI.