Publications by authors named "Cody A Prather"
Designing spray-dried particles for inhalation aims at specific physicochemical properties including a respirable aerodynamic diameter and adequate powder dispersibility. Leucine, an amphiphilic amino acid, has been shown to aid in optimizing bulk powder properties. Mannitol, a model crystalline active and common bulking agent, was co-sprayed with leucine at several excipient ratios, ethanol/water ratios, and spray dryer outlet temperatures in order to experimentally probe the underlying particle formation mechanisms in this binary crystalline system.
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- The study explores how immiscible two-phase flow of Newtonian fluids behaves in 3D porous media, focusing on the connection between volumetric flow rate and total pressure difference in steady state.
- It identifies a yield threshold created by capillary barriers that resembles the behavior of Bingham viscoplastic fluids, showing a quadratic relationship between flow rate and pressure drop under certain conditions.
- The researchers conducted experiments using a column of glass beads with deionized water and air, supported by numerical modeling of 3D pore networks, achieving consistent results across both methods.