Correction: f-Element heavy pnictogen chemistry.

[This corrects the article DOI: 10.1039/D3SC05056D.].

Metal-carbon bonding in early lanthanide substituted cyclopentadienyl complexes probed by pulsed EPR spectroscopy.

We examine lanthanide (Ln)-ligand bonding in a family of early Ln complexes [Ln(Cp)] (1-Ln, Ln = La, Ce, Nd, Sm; Cp = CHBu-1,3) by pulsed electron paramagnetic resonance (EPR) methods, and provide the first characterization of 1-La and 1-Nd by single crystal XRD, multinuclear NMR, IR and UV/Vis/NIR spectroscopy. We measure electron spin and relaxation times of 12 and 0.2 μs (1-Nd), 89 and 1 μs (1-Ce) and 150 and 1.

Activity and safety of enobosarm, a novel, oral, selective androgen receptor modulator, in androgen receptor-positive, oestrogen receptor-positive, and HER2-negative advanced breast cancer (Study G200802): a randomised, open-label, multicentre, multinational, parallel design, phase 2 trial.

Background: The androgen receptor is a tumour suppressor in oestrogen receptor-positive breast cancer. The activity and safety of enobosarm, an oral selective androgen receptor modulator, was evaluated in women with oestrogen receptor (ER)-positive, HER2-negative, and androgen receptor (AR)-positive disease.

Methods: Women who were postmenopausal (aged ≥18 years) with previously treated ER-positive, HER2-negative, locally advanced or metastatic breast cancer with an Eastern Cooperative Oncology Group performance status of 0-2 were enrolled in a randomised, open-label, multicentre, multinational, parallel design, phase 2 trial done at 35 cancer treatment centres in nine countries.

f-Element heavy pnictogen chemistry.

The coordination and organometallic chemistry of the f-elements, that is group 3, lanthanide, and actinide ions, supported by nitrogen ligands, amides, imides, and nitrides, has become well developed over many decades. In contrast, the corresponding f-element chemisty with the heavier pnictogen analogues phosphorus, arsenic, antimony, and bismuth has remained significantly underdeveloped, due largely to a lack of suitable synthetic methodologies and also the inherent hard(f-element)-soft(heavier pnictogen) acid-base mismatch, but has begun to flourish in recent years. Here, we review complexes containing chemical bonds between the f-elements and heavy pnictogens from phosphorus to bismuth that spans five decades of endeavour.

A multicenter evaluation of pediatric emergency department injury visits during the COVID-19 pandemic.

Background: Injuries, the leading cause of death in children 1-17 years old, are often preventable. Injury patterns are impacted by changes in the child's environment, shifts in supervision, and caregiver stressors. The objective of this study was to evaluate the incidence and proportion of injuries, mechanisms, and severity seen in Pediatric Emergency Departments (PEDs) during the COVID-19 pandemic.

Intraoperative immediate strength recovery following lacertus fibrosus release in patients with proximal median nerve compression at the elbow.

Purpose: In the literature, we find that patients with lacertus syndrome (LS), proximal median nerve compression at the elbow, present subjective improvement of thumb, and index flexion strength after lacertus fibrosus (LF) release. The aim of this study is to objectively evaluate the immediate change in intraoperative flexion strength after LF release.

Method: We retrospectively reviewed prospectively collected data of a cohort of 24 patients with a double crush syndrome of the median nerve with no response to conservative treatment.

Overcoming Barriers to Referral for Chimeric Antigen Receptor T Cell Therapy in Patients with Relapsed/Refractory Diffuse Large B Cell Lymphoma.

Diffuse large B cell lymphoma (DLBCL) is the most prevalent subtype of non-Hodgkin lymphoma. Although outcomes to frontline therapy are encouraging, patients who are refractory to or in relapse after first-line therapy experience inferior outcomes. A significant proportion of patients treated with additional lines of cytotoxic chemotherapy ultimately succumb to their disease, as established in the SCHOLAR-1 study.

Using simulated wildland fire to assess microbial survival at multiple depths from biocrust and bare soils.

Introduction: Surface soil microbial communities are directly exposed to the heat from wildland fires. Due to this, the microbial community composition may be stratified within the soil profile with more heat tolerant microbes near the surface and less heat tolerant microbes, or mobile species found deeper in the soil. Biological soil crusts, biocrusts, are found on the soil surface and contain a diverse microbial community that is directly exposed to the heat from wildland fires.

Impact of early detection on cancer curability: A modified Delphi panel study.

Expert consensus on the potential benefits of early cancer detection does not exist for most cancer types. We convened 10 practicing oncologists using a RAND/UCLA modified Delphi panel to evaluate which of 20 solid tumors, representing >40 American Joint Committee on Cancer (AJCC)-identified cancer types and 80% of total cancer incidence, would receive potential clinical benefits from early detection. Pre-meeting, experts estimated how long cancers take to progress and rated the current curability and benefit (improvement in curability) of an annual hypothetical multi-cancer screening blood test.

Severe Acute Respiratory Infection-Preparedness: Protocol for a Multicenter Prospective Cohort Study of Viral Respiratory Infections.

Unlabelled: Respiratory virus infections cause significant morbidity and mortality ranging from mild uncomplicated acute respiratory illness to severe complications, such as acute respiratory distress syndrome, multiple organ failure, and death during epidemics and pandemics. We present a protocol to systematically study patients with severe acute respiratory infection (SARI), including severe acute respiratory syndrome coronavirus 2, due to respiratory viral pathogens to evaluate the natural history, prognostic biomarkers, and characteristics, including hospital stress, associated with clinical outcomes and severity.

Design: Prospective cohort study.

Correction to: Efficacy and Safety of ABP 798: Results from the JASMINE Trial in Patients with Follicular Lymphoma in Comparison with Rituximab Reference Product.

Page 608, 4 Discussion, right column, second paragraph.

A comparison of eflapegrastim to pegfilgrastim in the management of chemotherapy-induced neutropenia in patients with early-stage breast cancer undergoing cytotoxic chemotherapy (RECOVER): A Phase 3 study.

Eflapegrastim (Rolontis ) is a novel, long-acting hematopoietic growth factor consisting of a recombinant human granulocyte-colony stimulating factor (rhG-CSF) analog conjugated to a human IgG4 Fc fragment via a short polyethylene glycol linker. We report results from a second pivotal, randomized, open-label, Phase 3 study comparing the efficacy and safety of eflapegrastim to pegfilgrastim for reducing the risk of chemotherapy-induced neutropenia. Patients with Stage I to IIIA early-stage breast cancer (ESBC) were randomized 1:1 to fixed-dose eflapegrastim 13.

A Uranium(VI)-Oxo-Imido Dimer Complex Derived from a Sterically Demanding Triamidoamine.

The reaction of [UO(μ-Cl){K(18-crown-6)}] with [{N(CHCHNSiPr)}Li] gives [{UO(μ-NCHCHN[CHCHNSiPr])}] (), [{(LiCl)(KCl)(18-crown-6)}] (), and [LiOSiPr] () in a 1:2:2 ratio. The formation of the oxo-imido involves the cleavage of a N-Si bond and the activation of one of the usually robust U═O bonds of uranyl(VI), resulting in the formation of uranium(VI)-imido and siloxide linkages. Notably, the uranium oxidation state remains unchanged at +6 in the starting material and product.

Eflapegrastim, a Long-Acting Granulocyte-Colony Stimulating Factor for the Management of Chemotherapy-Induced Neutropenia: Results of a Phase III Trial.

Background: Eflapegrastim, a novel, long-acting recombinant human granulocyte-colony stimulating factor (rhG-CSF), consists of a rhG-CSF analog conjugated to a human IgG4 Fc fragment via a short polyethylene glycol linker. Preclinical and phase I and II pharmacodynamic and pharmacokinetic data showed increased potency for neutrophil counts for eflapegrastim versus pegfilgrastim. This open-label phase III trial compared the efficacy and safety of eflapegrastim with pegfilgrastim for reducing the risk of chemotherapy-induced neutropenia.

Synthesis and characterisation of light lanthanide bis-phospholyl borohydride complexes.

Organometallic lanthanide (Ln) chemistry is dominated by complexes that contain substituted cyclopentadienyl (CpR) ligands. Closely related phospholyls have received less attention, and although they have proven utility in stabilising low oxidation state Ln complexes the trivalent Ln chemistry of these ligands is limited in comparison. Herein, we synthesise two families of heteroleptic Ln3+ complexes, [Ln(Htp)2(μ-BH4)]2 (Htp = 2,5-di-tert-butylphospholyl; 1-Ln; Ln = La, Ce, Nd, Sm), and [[Ln(Htp)2(μ-BH4)2K(S)]n (2-Ln, Ln = La, Ce, S = 2 DME, n = 2; 3-Ce, Ln = Ce, S = Et2O and THF, n = ∞) via the reactions of parent [Ln(BH4)3(THF)3.

Back-bonding between an electron-poor, high-oxidation-state metal and poor π-acceptor ligand in a uranium(V)-dinitrogen complex.

A fundamental bonding model in coordination and organometallic chemistry is the synergic, donor-acceptor interaction between a metal and a neutral π-acceptor ligand, in which the ligand σ donates to the metal, which π back-bonds to the ligand. This interaction typically involves a metal with an electron-rich, mid-, low- or even negative oxidation state and a ligand with a π* orbital. Here, we report that treatment of a uranium-carbene complex with an organoazide produces a uranium(V)-bis(imido)-dinitrogen complex, stabilized by a lithium counterion.

Recruitment of the motor system during music listening: An ALE meta-analysis of fMRI data.

Several neuroimaging studies have shown that listening to music activates brain regions that reside in the motor system, even when there is no overt movement. However, many of these studies report the activation of varying motor system areas that include the primary motor cortex, supplementary motor area, dorsal and ventral pre-motor areas and parietal regions. In order to examine what specific roles are played by various motor regions during music perception, we used activation likelihood estimation (ALE) to conduct a meta-analysis of neuroimaging literature on passive music listening.

Uranyl-tri- bis(silyl)amide Alkali Metal Contact and Separated Ion Pair Complexes.

We report the preparation of a range of alkali metal uranyl(VI) tri- bis(silyl)amide complexes [{M(THF) }{(μ-O)U(O)(N″)}] (1M) (N″ = {N(SiMe)}, M = Li, Na, x = 2; M = K, x = 3; M = K, Rb, Cs, x = 0) containing electrostatic alkali metal uranyl-oxo interactions. Reaction of 1M with 2,2,2-cryptand or 2 equiv of the appropriate crown ether resulted in the isolation of the separated ion pair species [U(O)(N″)][M(2,2,2-cryptand)] (3M, M = Li-Cs) and [U(O)(N″)][M(crown)] (4M, M = Li, crown = 12-crown-4 ether; M = Na-Cs, crown = 15-crown-5 ether). A combination of crystallographic studies and IR, Raman and UV-vis spectroscopies has revealed that the 1M series adopts contact ion pair motifs in the solid state where the alkali metal caps one of the uranyl-oxo groups.

A Very Short Uranium(IV)-Rhodium(I) Bond with Net Double-Dative Bonding Character.

Reaction of [U{C(SiMe )(PPh )}(BIPM)(μ-Cl)Li(TMEDA)(μ-TMEDA) ] (BIPM=C(PPh NSiMe ) ; TMEDA=Me NCH CH NMe ) with [Rh(μ-Cl)(COD)] (COD=cyclooctadiene) affords the heterotrimetallic U -Rh complex [U(Cl) {C(PPh NSiMe )(PPh[C H ]NSiMe )}{Rh(COD)}{Rh(CH(SiMe )(PPh )}]. This complex has a very short uranium-rhodium distance, the shortest uranium-rhodium bond on record and the shortest actinide-transition metal bond in terms of formal shortness ratio. Quantum-chemical calculations reveal a remarkable RhI→→ U net double dative bond interaction, involving Rh 4dz2 - and 4d -type donation into vacant U 5f orbitals, resulting in a Wiberg/Nalewajski-Mrozek U-Rh bond order of 1.

MDM2 Antagonists Counteract Drug-Induced DNA Damage.

Antagonists of MDM2-p53 interaction are emerging anti-cancer drugs utilized in clinical trials for malignancies that rarely mutate p53, including melanoma. We discovered that MDM2-p53 antagonists protect DNA from drug-induced damage in melanoma cells and patient-derived xenografts. Among the tested DNA damaging drugs were various inhibitors of Aurora and Polo-like mitotic kinases, as well as traditional chemotherapy.

Dietary sodium reduction does not affect circulating glucose concentrations in fasting children or adults: findings from a systematic review and meta-analysis.

Background: Although evidence shows that reduced sodium intake lowers blood pressure, some studies suggest that sodium reduction may adversely affect insulin resistance and glucose tolerance.

Objectives: The objectives were to assess the effects of sodium reduction on glucose tolerance, evaluate strengths and weaknesses of the relevant scientific literature, and provide direction for future research.

Methods: We searched The Cochrane Library, MEDLINE, EMBASE, CINAHL, and Web of Science through August 2014.