Enhanced luminescence and quenching mechanisms in Na⁺ Co-doped K₇CaY₂(B₅O₁₀)₃:Tb phosphors under UV radiation.

This study investigates the structural and luminescent properties UV radiation of Tb³⁺-doped K₇CaY₂(B₅O₁₀)₃ (KCYBO) phosphors prepared using a microwave-assisted sol-gel method, with a focus on the impact of Na⁺ co-doping. Tb³⁺ ions were effectively integrated as evidenced by X-ray diffraction (XRD) and Rietveld analysis, without disrupting the crystal structure. Photoluminescence (PL) analysis showed intense green emissions at 542 nm, which are due to the D₄ → F₅ transition in Tb³⁺.

Determination of Bone Fracture Risk in Kidney Transplant Recipients With FRAX Score.

Background: It is thought that the Fracture Risk Assessment Tool (FRAX) score of the World Health Organization (WHO) determines a 10-year fracture risk. This study aimed to investigate the major osteoporotic fracture (MOF) and hip fracture (HF) values determined with the FRAX score and practicality of the FRAX score in kidney transplant recipients (KTRs).

Methods: This study was conducted with 44 female and 59 male KTRs and 100 subjects in the healthy control group.

Relationship of Dickkopf-1 With Atherosclerosis and Arterial Stiffness in Renal Transplant Recipients.

Introduction: Dickkopf wingless (Wnt) signaling pathway inhibitor-1 (DKK-1) is a potent antagonist of the WNT canonical signaling pathway. DKK-1 is a substance that exerts anabolic effects on bone and is also involved in vascular cell regulation. The study aimed to determine the relationship of DKK-1 with atherosclerosis as determined by carotid artery intima-media thickness (CA-IMT) and arterial stiffness (AS) as determined by brachial-ankle pulse wave velocity (baPWV) in renal transplant recipients (RTRs).

High temperature photoluminescence dependence and energy migration of Tb-Incorporated KY(BO) phosphors.

This study investigates the structural and photoluminescence (PL) characteristics of Tb-incorporated KY(BO) (KYBO) phosphors synthesized via a microwave-assisted sol-gel technique. X-ray diffraction (XRD) and Rietveld refinement confirmed the formation of a pure hexagonal phase, with lattice expansion due to Tb³⁺ doping. PL studies revealed strong green emissions centered at 541 nm, attributed to the ⁵D₄ → ⁷F₅ transitions of Tb³⁺ ions, with the highest intensity observed at 5 wt% Tb³⁺.

Modulation of mechanosensitive genes during embryonic aortic arch development.

Background: Early embryonic aortic arches (AA) are a dynamic vascular structures that are in the process of shaping into the great arteries of cardiovascular system. Previously, a time-lapsed mechanosensitive gene expression map was established for AA subject to altered mechanical loads in the avian embryo. To validate this map, we investigated effects on vascular microstructure and material properties following the perturbation of key genes using an in-house microvascular gene knockdown system.

Improving Circulation Half-Life of Therapeutic Candidate N-TIMP2 by Unfolded Peptide Extension.

Matrix Metalloproteinases (MMPs) are drivers of many diseases including cancer and are established targets for drug development. Tissue inhibitors of metalloproteinases (TIMPs) are human proteins that inhibit MMPs and are being pursued for the development of anti-MMP therapeutics. TIMPs possess many attractive properties of a drug candidate, such as complete MMP inhibition, low toxicity and immunogenicity, high tissue permeability and others.

B Prognostic Index in Determining Prognosis in Metastatic Breast Cancer.

Objective: To determine the relationship between the B2 prognostic index (B2PI) scoring method and prognosis in metastatic breast cancer, and to create a formula based on parameters that can be easily accessed in daily practice.

Study Design: Descriptive study. Place and Duration of the Study: Department of Medical Oncology, Dokuz Eylul University, Izmir, Turkiye, between May 2010 and June 2021.

Enhanced luminescence of Eu in LaAlBO via energy transfer from Dy doping.

In this study, an investigation was conducted on the structural and photoluminescence (PL) characteristics of LaAlBO (LAB) phosphors initially incorporated with Dy and Eu ions. Subsequently, the impact of varying Eu concentration while maintaining a constant Dy concentration was examined. Structural characterization was performed using X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), and energy-dispersive X-ray spectroscopy (EDS).

Novel Tb³⁺-Doped LaAl₂B₄O₁₀ phosphors: Structural analysis, luminescent properties, and energy transfer mechanism.

This study explores the structural and luminescent properties of terbium (Tb³⁺)-doped lanthanum aluminium borate (LaAl₂B₄O₁₀, abbreviated as LAB) phosphors, a novel host lattice for Tb³⁺ doping. LAB:Tb³⁺ phosphors, with varying dopant concentrations, were synthesized using a microwave-assisted combustion synthesis approach and characterized using X-ray diffraction (XRD), Rietveld refinement, and photoluminescence spectroscopy at both room and low temperatures. The structural analysis confirmed the hexagonal crystal structure of LAB and revealed successful incorporation of Tb³⁺ ions without altering the fundamental lattice.

Investigation of Skull Cortical Thickness Changes in Healthy Population and Patients With Schizophrenia on Computed Tomography Images.

Cortical bone thickness is essential for the mechanical function of bone. Some factors including aging, sex, body size, hormone levels, behavior, and genetics lead to changes in cranial cortical robusticity. Moreover, the skull is one of the hardest and most durable structures in the human body.

Temperature-dependent photoluminescence of novel Eu, Tb, and Dy doped LaCaO(BO): Insights at low and room temperatures.

This study explores the structural and optical qualities of LaCaO(BO) (LACOB) phosphors doped with Eu, Dy, and Tb using a microwave-assisted sol-gel technique. It uncovers oxygen-related luminescence defects in LACOB, highlighting emission peaks at 489 and 585 nm for Dy, a distinct sharp peak at 611 nm for Eu in the red spectrum, and a notable green emission for Tb due to specific transitions. The photoluminescence (PL) analysis indicates that luminescence is optimized through precise doping, leveraging dipole interactions, and localized resonant energy transfer, which are influenced by dopant concentration and spatial configuration.

In Silico Investigation of Parkin-Activating Mutations Using Simulations and Network Modeling.

Complete loss-of-function mutations in the PRKN gene are a major cause of early-onset Parkinson's disease (PD). PRKN encodes the Parkin protein, an E3 ubiquitin ligase that works in conjunction with the ubiquitin kinase PINK1 in a distinct quality control pathway to tag damaged mitochondria for autophagic clearance, i.e.

The relationship between fear of old age, loneliness and death anxiety in adults.

Background: The increase in the number of elderly people in the world, individuals' perspectives on older adults, and false beliefs and ideas about old age negatively affect adults in terms of ageing. This study was conducted to determine the relationship between fear of old age, loneliness and death anxiety in adults.

Method: This study, which was designed in a correlational cross-sectional descriptive model, was conducted with 1074 adult individuals living in one province in eastern Turkey.

Temperature-responsive insights: Investigating Eu and Dy activated yttrium calcium oxyborate phosphors for structure and luminescence.

An investigation into the luminescent behavior of YCOB (Yttrium Calcium Oxyborate) doped with Eu and Dy ions, synthesized via the combustion method, is presented. The study, employing X-ray diffraction (XRD), Fourier-Transform Infrared Spectroscopy (FTIR), and Energy-Dispersive X-ray Spectroscopy (EDS) analyses, confirms the structural integrity and purity of the synthesized nanophosphors. An XRD pattern exhibiting distinct crystalline peaks indicates that the dopant ions were successfully integrated into the YCOB lattice.

Structure and computation-guided yeast surface display for the evolution of TIMP-based matrix metalloproteinase inhibitors.

The study of protein-protein interactions (PPIs) and the engineering of protein-based inhibitors often employ two distinct strategies. One approach leverages the power of combinatorial libraries, displaying large ensembles of mutant proteins, for example, on the yeast cell surface, to select binders. Another approach harnesses computational modeling, sifting through an astronomically large number of protein sequences and attempting to predict the impact of mutations on PPI binding energy.

Novel Sm doped YCaO(BO) phosphors: Structural and, low and room temperature luminescent insights.

Inorganic phosphors, known for their ability to capture energy from various sources and emit visible light, have become essential in the development of advanced lighting and display technologies. This study explores YCaO(BO) (YCOB) as a potential host material for phosphors, focusing on the luminescent properties of YCOB phosphors doped with Sm ions. The successful integration of Sm ions into the YCOB host lattice is confirmed through structural characterization using X-ray diffraction (XRD), Fourier-Transform Infrared Spectroscopy (FTIR), and Energy-Dispersive X-ray Spectroscopy (EDS).

Statistical Mechanics Metrics in Pairing and Parsing In Silico and Phenotypic Data of a Novel Genetic NFκB1 (c.T638A) Variant.

(1) Background: Mutations in , a transcriptional regulator of immunomodulating proteins, are a known cause of inborn errors of immunity. Our proband is a 22-year-old male with a diagnosis of common variable immunodeficiency (CVID), cytopenias with massive splenomegaly, and nodular regenerative hyperplasia of the liver. Genetic studies identified a novel, single-point mutation variant in , c.

[A Case Report on Subarachnoid Hemorrhage Secondary to Neurobrucellosis in a Patient with Cerebral Aneurysm].

Brucellosis is a multisystemic infection produced by a gram-negative bacillus that can develop a variety of clinical symptoms and complications. Involvement of the central nervous system is a challenging and dangerous consequence of systemic brucellosis. The neurobrucellosis clinical spectrum can be classified as central and peripheral.

Left Atrial Ligation in the Avian Embryo as a Model for Altered Hemodynamic Loading During Early Vascular Development.

Due to its four-chambered mature ventricular configuration, ease of culture, imaging access, and efficiency, the avian embryo is a preferred vertebrate animal model for studying cardiovascular development. Studies aiming to understand the normal development and congenital heart defect prognosis widely adopt this model. Microscopic surgical techniques are introduced to alter the normal mechanical loading patterns at a specific embryonic time point and track the downstream molecular and genetic cascade.

Unveiling an indole alkaloid diketopiperazine biosynthetic pathway that features a unique stereoisomerase and multifunctional methyltransferase.

The 2,5-diketopiperazines are a prominent class of bioactive molecules. The nocardioazines are actinomycete natural products that feature a pyrroloindoline diketopiperazine scaffold composed of two D-tryptophan residues functionalized by N- and C-methylation, prenylation, and diannulation. Here we identify and characterize the nocardioazine B biosynthetic pathway from marine Nocardiopsis sp.

Reconsidering the environmental Kuznets curve, pollution haven, and pollution halo hypotheses with carbon efficiency in China: A dynamic ARDL simulations approach.

Given a new perspective on the environmental hypothesis, this paper systematically investigates the validity of the environmental Kuznets curve (EKC), pollution haven, and pollution halo hypotheses using carbon efficiency as the dependent variable. Applying the dynamic autoregressive distributed lag simulations based on the annual time series data over the period 1990-2019, the study found that real GDP per capita has negative effects on China's environmental quality both in the short and long run, whereas the square of real GDP per capita has positive impacts. This validates the EKC hypothesis for China.