Publications by authors named "Cmiel A"

Background: Nonsteroidal anti-inflammatory drugs-exacerbated respiratory disease (NSAIDs-ERD) is characterized by altered arachidonic acid (AA) metabolism. Aspirin hypersensitivity is diagnosed using aspirin challenge, while induced sputum is collected to perform cell counts and to identify local biomarkers in induced sputum supernatant (ISS). This study aimed to assess the levels of a newly identified eicosanoid, 15-oxo-eicosatetraenoic acid (15-oxo-ETE), in ISS at baseline and during aspirin-induced bronchospasm in patients with NSAIDs-ERD.

View Article and Find Full Text PDF
Article Synopsis
  • 15-oxo-eicosatetraenoic acid (15-oxo-ETE) is linked to arachidonic acid metabolism and was found to be overproduced in patients with nonsteroidal anti-inflammatory drug-exacerbated respiratory disease (N-ERD).
  • A study involving patients with N-ERD, asthmatics who tolerate aspirin, and healthy controls measured levels of 15-oxo-ETE and leukotriene E (LTE) to evaluate their potential as diagnostic markers.
  • Results showed that 15-oxo-ETE levels were significantly higher in N-ERD patients, leading to the development of the Aspirin Hypersensitivity Diagnostic Index (AHDI) which showed strong accuracy in
View Article and Find Full Text PDF

The largest rivers in developed countries have usually been turned into waterways by straightening them and removing large bedforms hampering navigation. For river restoration and their sustainable management it is important to know how large bedforms support biodiversity, whether they could be protected and what potential conflicts in river management they can pose. We have addressed these questions by studying the role of large bedforms in supporting populations of two inland tern species Sternula albifrons and Sterna hirundo.

View Article and Find Full Text PDF

: The literature review shows that female patients are more frequently underdiagnosed or suffer from delayed diagnosis. Recognition of sex-related differences is crucial for implementing strategies to improve cardiovascular outcomes. We aimed to assess sex-related disparities in the frequency of fractional flow reserve (FFR)-guided procedures in patients who underwent angiography and/or percutaneous coronary intervention (PCI).

View Article and Find Full Text PDF

Background: Bronchial thermoplasty (BT) is an interventional endoscopic treatment for severe asthma leading to the clinical improvement, but morphologic changes of bronchial wall related to the procedure and predictors of a favorable response to BT remain uncertain. The aim of the study was to validate an endobronchial ultrasound (EBUS) in assessing the effectiveness of BT treatment.

Methods: Patients with severe asthma who met the clinical criteria for BT were included.

View Article and Find Full Text PDF

Background: The cellular inflammatory pattern of nonsteroidal anti-inflammatory drug-exacerbated respiratory disease (N-ERD) is heterogeneous. However, data on the heterogeneity of non-eosinophilic asthma (NEA) with aspirin hypersensitivity are scanty. By examination of N-ERD patients based on clinical data and eicosanoid biomarkers we aimed to identify NEA endotypes potentially guiding clinical management.

View Article and Find Full Text PDF

Background: During the coronavirus disease 2019 (COVID-19) pandemic, it has become a pressing need to be able to diagnose aspirin hypersensitivity in patients with asthma without the need to use oral aspirin challenge (OAC) testing. OAC is time consuming and is associated with the risk of severe hypersensitive reactions. In this study, we sought to investigate whether machine learning (ML) based on some clinical and laboratory procedures performed during the pandemic might be used for discriminating between patients with aspirin hypersensitivity and those with aspirin-tolerant asthma.

View Article and Find Full Text PDF

There is a great need to understand the impact of complex communities on the free-living parasite stages that are part of them. This task becomes more complex as nonnative species emerge, changing existing relationships and shaping new interactions in the community. A relevant question would be: Can the coexistence of nontarget snails with the target hosts contribute to trematodasis control? We used field and experimental approaches to investigate nonnative competitor-induced parasite dilution.

View Article and Find Full Text PDF

Introduction: Lung cancer patients (LCP) require invasive evaluation of left adrenal glands (LAG) if distant metastases (M1b/1c) are suspected in CT or PET-CT. Only few studies showed utility of endosonography and particularly EUS-b-FNA as minimally invasive endoscopic method of LAG analysis.

Material And Methods: A retrospective study of consecutive LCP was conducted in two pulmonology centers between January 2010 and December 2019.

View Article and Find Full Text PDF

The naiads, large freshwater mussels (Unionida), have very long life spans, are large-bodied, and produce thousands to millions of larvae (glochidia) which typically must attach to host fish tissues to metamorphose into a juvenile mussel. Glochidia develop within a female's marsupial gill demibranch, thus their number is restricted by female size. However, larger mussels acquire more energy, which could be invested in either larger-sized glochidia, in a more glochidia, or a combination of both.

View Article and Find Full Text PDF

Introduction: Patients with resectable lung cancer require invasive evaluation of the enlarged left adrenal gland (LAG). Few studies showed the utility of endoscopic ultrasound using ultrasound bronchoscope (EUS‑B) in LAG assessment. Moreover, little is known on the combination of computed tomography (CT), positron emission tomography-computed tomography (PET‑CT), and EUS‑B for predicting left adrenal metastasis.

View Article and Find Full Text PDF

A simple method is utilised to study and compare COVID-19 infection dynamics between countries based on curve fitting to publicly shared data of confirmed COVID-19 infections. The method was tested using data from 80 countries from 6 continents. We found that Johnson cumulative density functions (CDFs) were extremely well fitted to the data (R > 0.

View Article and Find Full Text PDF

Objectives: This study aimed to analyze the effect of bilateral mediastinal lymphadenectomy (BML) on survival of non-small cell lung cancer (NSCLC) patients. The hypothesis was: BML offers survival benefit as compared with SLND.

Methods: A randomized clinical trial including stage I-IIIA NSCLC patients was performed.

View Article and Find Full Text PDF

Background: Aspirin desensitization followed by daily aspirin use is an effective treatment for aspirin-exacerbated respiratory disease (AERD).

Objective: To assess clinical features as well as genetic, immune, cytological and biochemical biomarkers that might predict a positive response to high-dose aspirin therapy in AERD.

Methods: We enrolled 34 AERD patients with severe asthma who underwent aspirin desensitization followed by 52-week aspirin treatment (650 mg/d).

View Article and Find Full Text PDF
Article Synopsis
  • AAV (ANCA-associated vasculitides) include a range of rare diseases, and there's a significant need for better classification, particularly in granulomatosis with polyangiitis (GPA) patients.
  • A study using latent class analysis (LCA) on Polish AAV patients identified four subcategories of AAV instead of the previously proposed three, highlighting a new clinically relevant group with specific characteristics.
  • This newly identified group of GPA patients is younger, exhibits multiorgan involvement, has a high relapse rate, and poses a higher risk of mortality, indicating the need for prompt and aggressive treatment.
View Article and Find Full Text PDF

Introduction: Needle biopsy of enlarged lymph nodes is an accepted method for the diagnostic workup of sarcoidosis, but the optimal endosonography‑guided approach is yet to be determined.

Objectives: The aim of our study was to assess the relative diagnostic yield of combined ultrasound‑guided needle aspiration (CUS‑b‑NA), which includes endobronchial ultrasound‑guided transbronchial needle aspiration (EBUS‑TBNA) with endoscopic ultrasound fine‑needle aspiration (EUS‑b‑FNA), as well as the role of the cell block (CB) technique and lymph node localization in the diagnostic workup of sarcoidosis.

Patients And Methods: This was a prospective multicenter study including consecutive patients with clinical suspicion of stage I or II sarcoidosis.

View Article and Find Full Text PDF

Background: To date, there has been no reliable in vitro test to either diagnose or differentiate nonsteroidal anti-inflammatory drug (NSAID)-exacerbated respiratory disease (N-ERD). The aim of the present study was to develop and validate an artificial neural network (ANN) for the prediction of N-ERD in patients with asthma.

Methods: This study used a prospective database of patients with N-ERD (n = 121) and aspirin-tolerant (n = 82) who underwent aspirin challenge from May 2014 to May 2018.

View Article and Find Full Text PDF

Background: Induced sputum (IS) allows to measure mediators of asthmatic inflammation in bronchial secretions. NSAID-exacerbated respiratory disease (NERD) is recognized as a distinct asthma phenotype, usually with a severe course, eosinophilic airway inflammation, and increased production of pro-inflammatory eicosanoids. A more insightful analysis of NERD patients has shown this phenotype to be nonhomogeneous.

View Article and Find Full Text PDF

Although eutrophication of freshwaters is a natural process, the human impact often leads to inland waters becoming overloaded with nutrients, impoverishing many valuable and vanishing habitats, such as floodplain lakes. These changes need to be reversed if the occurrence of endangered aquatic species is to be restored. In this paper we analyse the impact of a change in the water regime of a naturally eutrophic floodplain lake, which harbours a large diversity of Unionidae (large freshwater mussels), a globally threatened taxonomic group that provides important ecosystem functions and services.

View Article and Find Full Text PDF

Background: Aspirin desensitization (AD) is an effective and safe therapeutic option for patients with nonsteroidal anti-inflammatory drugs (NSAIDs)-exacerbated respiratory disease (N-ERD). The mechanisms driving its beneficial effects remain poorly understood.

Objective: To investigate the effect of long-term AD on clinical, biochemical and radiological changes in N-ERD patients.

View Article and Find Full Text PDF