Publications by authors named "Clothilde Lindet-Bourgeois"
Purpose: The introduction of PARP inhibitors (PARPis) as a treatment option for patients with high-grade serous ovarian cancer (HGSOC) modified the approach of testing worldwide. In this study, we aim to evaluate the impact of and variants on treatment response and survival outcomes in patients diagnosed in our institution.
Methods: A total of 805 HGSOC samples underwent and variant detection by using next-generation sequencing (NGS).
Article Synopsis
- Cowden syndrome (CS) is a genetic disorder marked by macrocephaly, skin lesions, and heightened risk of certain cancers, especially breast and thyroid cancers.
- A 28-year-old woman with CS developed ovarian clear cell carcinoma (OCCC) and exhibited related physical symptoms and family cancer history.
- Genetic testing revealed a pathogenic variant in her tumor, suggesting a link between CS and her OCCC, which prompts reconsideration of the cancer spectrum associated with Cowden syndrome.