Age reduces resistance and tolerance in malaria-infected mice.

Once infected, hosts can rely on two strategies to cope with parasites: fight them (resist the infection) or minimize the damage they induce (tolerate the infection). While there is evidence that aging reduces resistance, how tolerance varies as hosts become old has been barely studied. Here, we used a rodent malaria parasite (Plasmodium yoelii) to investigate whether 2- and 12-month old house mice differ in their capacity to resist and tolerate the infection.

Azole-resistant Aspergillus fumigatus in the hospital: Surveillance from flower beds to corridors.

Screening has been performed for azole-resistant Aspergillus fumigatus in the indoor air of the hospital since 2015 and in soil and dust samples since January 2019. In total, 83 azole-resistant A fumigatus isolates with a TR/L98H mutation have been obtained: 1 from the air of the intensive care unit, 16 from the main corridors, 59 from pots of tulips imported from the Netherlands, and 5 from the soil of trees grown in pots.

Hemp to limit diffusion of difenoconazole in vegetable garden soils.

Triazole molecules are used to manage invasive aspergillosis, a fungal infection mainly due to . is not a phytopathogen, but, as it is widespread in soils, triazole fungicides have an unintended impact on it, selecting resistant populations' in environment. Thus, to maintain our ability to control fungal infections, whether in human health or agriculture, reduce the impact of the use of triazoles in the environment is important, notably limiting their diffusion in soils.

Determination of azole fungal residues in soils and detection of Aspergillus fumigatus-resistant strains in market gardens of Eastern France.

Medical azole antifungals are major compounds used to prevent and to treat invasive aspergillosis (IA). Azole fungicides, called DMI (14-alpha demethylase inhibitors), are also widely used for crop protection and have been reported to be linked to azole-resistant A. fumigatus (aR-Af) development in the environment.