Publications by authors named "Cloe Gadenne"
Article Synopsis
- Chronic HBV infection leads to severe liver disease and liver cancer, and new antiviral treatments like Capsid Assembly Modulators (CAMs) are needed but not fully understood in their mechanism of action.
- Recent research demonstrates that CAM-A compounds reduce HBsAg levels and cause cell death in HBV-infected cells by promoting the aggregation of HBV core proteins (HBc) in the nucleus, triggering apoptosis.
- Discovering that CAM-A facilitates HBc aggregation and activates apoptosis provides insights for developing new therapies aimed at effectively managing chronic HBV infections.
Chronic liver disease and cancer are global health challenges. The role of the circadian clock as a regulator of liver physiology and disease is well established in rodents, however, the identity and epigenetic regulation of rhythmically expressed genes in human disease is less well studied. Here we unravel the rhythmic transcriptome and epigenome of human hepatocytes using male human liver chimeric mice.
View Article and Find Full Text PDFBackground & Aims: Liver fibrosis is the major driver of hepatocellular carcinoma and liver disease-related death. Approved antifibrotic therapies are absent and compounds in development have limited efficacy. Increased TGF-β signaling drives collagen deposition by hepatic stellate cells (HSCs)/myofibroblasts.
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