Total homocysteine is associated with white matter hyperintensity volume: the Northern Manhattan Study.

Background: Total homocysteine (tHcy) has been implicated as a risk factor for stroke and dementia, but the mechanism is unclear. White matter hyperintensities may be a risk factor for both, but studies of the relationship between tHcy and quantitative measures of white matter hyperintensity volume (WMHV) are lacking, especially in minority populations.

Methods: A community-based sample of 259 subjects with baseline tHcy levels underwent pixel-based quantitative measurement of WMHV.

Ischemic stroke subtype incidence among whites, blacks, and Hispanics: the Northern Manhattan Study.

Background: Stroke incidence is greater in blacks than in whites; data on Hispanics are limited. Comparing subtype-specific ischemic stroke incidence rates may help to explain race-ethnic differences in stroke risk. The aim of this population-based study was to determine ischemic stroke subtype incidence rates for whites, blacks, and Hispanics living in one community.