Unified modeling of photothermal and photochemical damage.

Correlating damage outcomes to a retinal laser exposure is critical for diagnosis and choosing appropriate treatment modalities. Therefore, it is important to understand the causal relationships between laser parameters, such as wavelength, power density, and length of exposure, and any resulting injury. Differentiating photothermal from photochemical processes in an retinal model using cultured retinal pigment epithelial cells would be a first step in achieving this goal.

Infrared skin damage thresholds from 1319-nm continuous-wave laser exposures.

A series of experiments were conducted in vivo using Yucatan miniature pigs (Sus scrofa domestica) to determine thermal damage thresholds to the skin from 1319-nm continuous-wave Nd:YAG laser irradiation. Experiments employed exposure durations of 0.25, 1.

Spatially correlated microthermography maps threshold temperature in laser-induced damage.

We measured threshold temperatures for cell death resulting from short (0.1-1.0 s) 514-nm laser exposures using an in vitro retinal model.

Mathematical model that describes the transition from thermal to photochemical damage in retinal pigment epithelial cell culture.

We propose a rate process model for describing photochemical damage to retinal cells by short wavelength laser exposures. The rate equation for photochemical damage contains a positive rate that is temperature independent, and a negative (quenching) rate that is temperature dependent. Using the traditional Arrhenius integral to describe thermal damage, we derive damage threshold doses for both thermal and photochemical mechanisms, and show that the model accounts for the sharp transition from thermal to photochemical damage thresholds that have recently been observed in an in-vitro retinal model.

First-order model of thermal lensing in a virtual eye.

An ABCD beam-propagation method was used to build a first-order mathematical model of a thermal lens effect from a near-infrared laser beam in water and ocular media. The model was found to fit experimental z-scan data best when the thermo-optic coefficient dn/dT of liquid water at 292 K was -4.46x10(-5) K(-1).