Synopsis of recent research by authors named "Clifford Jack"
Recent research by Clifford Jack focuses on the intersection of genetic, imaging, and clinical factors influencing brain health, particularly concerning Alzheimer's disease and other neurodegenerative conditions.
Key findings include the establishment of polygenic scores linked to subcortical brain structures, revealing significant genetic loci associated with brain volume variations, and identifying novel biomarkers related to cerebral small vessel disease through comprehensive plasma proteomic analysis.
His work also explores advanced imaging techniques, such as F-flortaucipir PET, to improve the antemortem diagnosis of tau pathologies and assesses the predictive capacity of multimodal imaging in tracking cognitive decline in atypical Alzheimer's disease.
