Efficacy and safety of leuprolide acetate 3-month depot 11.25 milligrams or 30 milligrams for the treatment of central precocious puberty.

Context: GnRH agonist (GnRHa) monthly injections are frequently used in the treatment of central precocious puberty (CPP). The 3-month leuprolide depot 11.25- and 30-mg formulations are newly approved treatment options.

Caregiver reports of provider recommended frequency of blood glucose monitoring and actual testing frequency for youth with type 1 diabetes.

Aims: To identify demographic, family and clinical characteristics associated with provider recommended frequency of blood glucose monitoring (BGM), actual frequency of BGM, and concordance between these categories in youth with type 1 diabetes (T1D) as reported by child's caregiver.

Methods: Caregivers of 390 children 10-17 years were interviewed about their children's providers' recommendations for frequency of BGM and their child's frequency of performance of BGM.

Results: The majority (92%) of caregivers reported being told that their child should BGM ≥4 times per day and 78% reported their child checked that frequently.

Leuprolide acetate 1-month depot for central precocious puberty: hormonal suppression and recovery.

Methods. This prospective US multicenter trial of leuprolide acetate 1-month depot (7.5-15 mg) for central precocious puberty utilized an open-label treatment period, long-term follow-up, and adult callback.

Family history of diabetes, autoimmunity, and risk factors for cardiovascular disease among children with diabetes in the SEARCH for Diabetes in Youth Study.

Background: While type 1 diabetes and type 2 diabetes (T2D) are considered etiologically distinct, mixed features of autoimmunity and insulin resistance are increasingly common. We explored a familial contribution to this admixture by evaluating diabetes family history (FH) and its relationship to diabetes type, ethnicity, age at diagnosis, and cardiovascular risk factors in SEARCH for Diabetes in Youth Study participants.

Methods: Diabetes FH was assessed by questionnaire, with FH categories defined by relative's(s') age at diagnosis as follows: <25 (early FH), >/=25 (later FH), and both <25 and >/=25 (mixed FH).

Prepubertal gynecomastia linked to lavender and tea tree oils.

Most cases of male prepubertal gynecomastia are classified as idiopathic. We investigated possible causes of gynecomastia in three prepubertal boys who were otherwise healthy and had normal serum concentrations of endogenous steroids. In all three boys, gynecomastia coincided with the topical application of products that contained lavender and tea tree oils.

Congenital hypothyroidism and the second newborn metabolic screening in Colorado, USA.

Objective: To evaluate the effectiveness of a second newborn screening for congenital hypothyroidism (CH).

Methods: All infants born in Colorado, USA, from July 1996 through June 2004 had a total thyroxine measured with secondary thyroid stimulating hormone determination.

Results: The number of first and second newborn screens completed was 494,324 and 471,877, respectively.