Mitogen-activated protein kinase signalling in rat hearts during postnatal development: MAPKs, MAP3Ks, MAP4Ks and DUSPs.

Mammalian cardiomyocytes become terminally-differentiated during the perinatal period. In rodents, cytokinesis ceases after a final division cycle immediately after birth. Nuclear division continues and most cardiomyocytes become binucleated by ∼11 days.

Management of Potential Organ Donor: Indian Society of Critical Care Medicine-Position Statement.

Unlabelled: This position statement is documented based on the input from all contributing coauthors from the Indian Society of Critical Care Medicine (ISCCM), following a comprehensive literature review and summary of current scientific evidence. Its objective is to provide the standard perspective for the management of potential organ/tissue donors after brain death (BD) in adults only, regardless of the availability of technology. This document should only be used for guidance only and is not a substitute for proper clinical decision making in particular circumstances of any case.

Position Statement of ISCCM Committee on Weaning from Mechanical Ventilator.

Background And Purpose: Weaning from a mechanical ventilator is a milestone in the recovery of seriously ill patients in Intensive care. Failure to wean and re-intubation adversely affects the outcome. The method of mechanical ventilation (MV) varies between different ICUs and so does the practice of weaning.

Measurement and Feed Forward Induced Entanglement Negativity Transition.

We study the interplay between measurement-induced dynamics and conditional unitary evolution in quantum systems. We numerically and analytically investigate commuting random measurement and feed forward (MFF) processes and find a sharp transition in their ability to generate entanglement negativity as the number of MFF channels varies. We also establish a direct connection between these findings and transitions induced by random dephasing from an environment with broken time-reversal symmetry.

Understanding Central Spin Decoherence Due to Interacting Dissipative Spin Baths.

We propose a new approach to simulate the decoherence of a central spin coupled to an interacting dissipative spin bath with cluster-correlation expansion techniques. We benchmark the approach on generic 1D and 2D spin baths and find excellent agreement with numerically exact simulations. Our calculations show a complex interplay between dissipation and coherent spin exchange, leading to increased central spin coherence in the presence of fast dissipation.

Striatin plays a major role in angiotensin II-induced cardiomyocyte and cardiac hypertrophy in mice in vivo.

The three striatins (STRN, STRN3, STRN4) form the core of STRiatin-Interacting Phosphatase and Kinase (STRIPAK) complexes. These place protein phosphatase 2A (PP2A) in proximity to protein kinases thereby restraining kinase activity and regulating key cellular processes. Our aim was to establish if striatins play a significant role in cardiac remodelling associated with cardiac hypertrophy and heart failure.

Dispersive nonreciprocity between a qubit and a cavity.

The dispersive interaction between a qubit and a cavity is ubiquitous in circuit and cavity quantum electrodynamics. It describes the frequency shift of one quantum mode in response to excitations in the other and, in closed systems, is necessarily bidirectional, i.e.

Quantum simulation of the bosonic Kitaev chain.

Superconducting quantum circuits are a natural platform for quantum simulations of a wide variety of important lattice models describing topological phenomena, spanning condensed matter and high-energy physics. One such model is the bosonic analog of the well-known fermionic Kitaev chain, a 1D tight-binding model with both nearest-neighbor hopping and pairing terms. Despite being fully Hermitian, the bosonic Kitaev chain exhibits a number of striking features associated with non-Hermitian systems, including chiral transport and a dramatic sensitivity to boundary conditions known as the non-Hermitian skin effect.

Are "High-alert Medication" Used Safely in Intensive Care Units?

Clerk AM. Are "High-alert Medication" Used Safely in Intensive Care Units? Indian J Crit Care Med 2023;27(12):871-872.

Exact Solution of the Infinite-Range Dissipative Transverse-Field Ising Model.

The dissipative variant of the Ising model in a transverse field is one of the most important models in the analysis of open quantum many-body systems, due to its paradigmatic character for understanding driven-dissipative quantum phase transitions, as well as its relevance in modeling diverse experimental platforms in atomic physics and quantum simulation. Here, we present an exact solution for the steady state of the transverse-field Ising model in the limit of infinite-range interactions, with local dissipation and inhomogeneous transverse fields. Our solution holds despite the lack of any collective spin symmetry or even permutation symmetry.

Squeezed Superradiance Enables Robust Entanglement-Enhanced Metrology Even with Highly Imperfect Readout.

Quantum metrology protocols using entangled states of large spin ensembles attempt to achieve measurement sensitivities surpassing the standard quantum limit (SQL), but in many cases they are severely limited by even small amounts of technical noise associated with imperfect sensor readout. Amplification strategies based on time-reversed coherent spin-squeezing dynamics have been devised to mitigate this issue, but are unfortunately very sensitive to dissipation, requiring a large single-spin cooperativity to be effective. Here, we propose a new dissipative protocol that combines amplification and squeezed fluctuations.

Arrest Outcome Consortium Registry Analysis [AOCRA 2022]: Outcome Statistics of Cardiac Arrest in Tertiary Care Hospitals in India, Analysis of Five Year Data of Indian Online Cardiac Arrest Registry, www.aocregistry.com.

Aim And Background: To publish data with outcome statistics from our online cardiac arrest (CA) outcome consortium (AOC) online registry.

Materials And Methods: Data on cardiac arrest (CA) from tertiary care hospitals were collected on the AOC registry online portal from January 2017 to May 2022. Survival endpoints from cardiac arrest events like ROSC, and survival at hospital discharge with neurological status at discharge were analyzed and presented.

Dissipative Pairing Interactions: Quantum Instabilities, Topological Light, and Volume-Law Entanglement.

We analyze an unusual class of bosonic dynamical instabilities that arise from dissipative (or non-Hermitian) pairing interactions. We show that, surprisingly, a completely stable dissipative pairing interaction can be combined with simple hopping or beam-splitter interactions (also stable) to generate instabilities. Further, we find that the dissipative steady state in such a situation remains completely pure up until the instability threshold (in clear distinction from standard parametric instabilities).

Single-Spin Readout and Quantum Sensing Using Optomechanically Induced Transparency.

Solid-state spin defects are promising quantum sensors for a large variety of sensing targets. Some of these defects couple appreciably to strain in the host material. We propose to use this strain coupling for mechanically mediated dispersive single-shot spin readout by an optomechanically induced transparency measurement.

Competencies for Point-of-care Ultrasonography in ICU: An ISCCM Expert Panel Practice Recommendation.

Srinivasan S, Kumar PG, Govil D, Gupta S, Kumar V, Pichamuthu K, . Competencies for Point-of-care Ultrasonography in ICU: An ISCCM Expert Panel Practice Recommendation. Indian J Crit Care Med 2022;26(S2):S7-S12.

Sepsis in Intensive Care Unit: Which Score Predicts Better about Outcome?

Clerk AM. Sepsis in Intensive Care Unit: Which Score Predicts Better about Outcome? Indian J Crit Care Med 2022;26(10):1072-1073.

Competition between Two-Photon Driving, Dissipation, and Interactions in Bosonic Lattice Models: An Exact Solution.

We present an exact solution in arbitrary dimensions for the steady states of a class of quantum driven-dissipative bosonic models, where a set of modes is subject to arbitrary two-photon driving, single-photon loss, and a global Hubbard (or Kerr)-like interaction. Our solutions reveal a wealth of striking phenomena, including the emergence of dissipative phase transitions, nontrivial mode competition physics and symmetry breaking, and the stabilization of many-body SU(1,1) pair-coherent states. Our exact solutions enable the description of spatial correlations, and are fully valid in regimes where traditional mean-field and semiclassical approaches break down.

Surpassing spectator qubits with photonic modes and continuous measurement for Heisenberg-limited noise mitigation.

Noise is an ever-present challenge to the creation and preservation of fragile quantum states. Recent work suggests that spatial noise correlations can be harnessed as a resource for noise mitigation via the use of spectator qubits to measure environmental noise. In this work we generalize this concept from spectator qubits to a spectator mode: a photonic mode which continuously measures spatially correlated classical dephasing noise and applies a continuous correction drive to frequency-tunable data qubits.

Cardiomyocyte BRAF is a key signalling intermediate in cardiac hypertrophy in mice.

Cardiac hypertrophy is necessary for the heart to accommodate an increase in workload. Physiological, compensated hypertrophy (e.g.

Asymmetry-Based Quantum Backaction Suppression in Quadratic Optomechanics.

As the field of optomechanics advances, quadratic dispersive coupling (QDC) represents an increasingly feasible path toward qualitatively new functionality. However, the leading QDC geometries generate linear dissipative coupling and an associated quantum radiation force noise that is detrimental to QDC applications. Here, we propose a simple geometry that dramatically reduces this noise without altering the QDC strength.

The insulin receptor family in the heart: new light on old insights.

Insulin was discovered over 100 years ago. Whilst the first half century defined many of the physiological effects of insulin, the second emphasised the mechanisms by which it elicits these effects, implicating a vast array of G proteins and their regulators, lipid and protein kinases and counteracting phosphatases, and more. Potential growth-promoting and protective effects of insulin on the heart emerged from studies of carbohydrate metabolism in the 1960s, but the insulin receptors (and the related receptor for insulin-like growth factors 1 and 2) were not defined until the 1980s.

PKN2 deficiency leads both to prenatal 'congenital' cardiomyopathy and defective angiotensin II stress responses.

The protein kinase PKN2 is required for embryonic development and PKN2 knockout mice die as a result of failure in the expansion of mesoderm, cardiac development and neural tube closure. In the adult, cardiomyocyte PKN2 and PKN1 (in combination) are required for cardiac adaptation to pressure-overload. The specific role of PKN2 in contractile cardiomyocytes during development and its role in the adult heart remain to be fully established.

Distinguishing between Quantum and Classical Markovian Dephasing Dissipation.

Understanding whether dissipation in an open quantum system is truly quantum is a question of both fundamental and practical interest. We consider n qubits subject to correlated Markovian dephasing and present a sufficient condition for when bath-induced dissipation can generate system entanglement and hence must be considered quantum. Surprisingly, we find that the presence or absence of time-reversal symmetry plays a crucial role: broken time-reversal symmetry is required for dissipative entanglement generation.

Cardiomyocyte BRAF and type 1 RAF inhibitors promote cardiomyocyte and cardiac hypertrophy in mice in vivo.

The extracellular signal-regulated kinase 1/2 (ERK1/2) cascade promotes cardiomyocyte hypertrophy and is cardioprotective, with the three RAF kinases forming a node for signal integration. Our aims were to determine if BRAF is relevant for human heart failure, whether BRAF promotes cardiomyocyte hypertrophy, and if Type 1 RAF inhibitors developed for cancer (that paradoxically activate ERK1/2 at low concentrations: the 'RAF paradox') may have the same effect. BRAF was up-regulated in heart samples from patients with heart failure compared with normal controls.