Habitual Running Style Matters: Duty Factor, and Not Stride Frequency, Relates to Loading Magnitude.

Running style is temporally defined by a duty factor and stride frequency and believed to be related to the loading experienced during ever step. However, the exact relationship between both temporal variables and loading magnitude is still unknown. We aimed to identify the relationship between a duty factor and stride frequency with external load measures, joint reaction forces and joint moments.

Large language models can help boost food production, but be mindful of their risks.

Coverage of ChatGPT-style large language models (LLMs) in the media has focused on their eye-catching achievements, including solving advanced mathematical problems and reaching expert proficiency in medical examinations. But the gradual adoption of LLMs in agriculture, an industry which touches every human life, has received much less public scrutiny. In this short perspective, we examine risks and opportunities related to more widespread adoption of language models in food production systems.

Peak tibial accelerations in different foot strike patterns during level running: an independent investigation in different cohorts.

Peak tibial accelerations are used to monitor impact severity during distance running and as input for bio-feedback. Here, peak tibial accelerations were compared between rearfoot and forefoot strikes. Two different studies were undertaken by independent research centres.

An Injury Prevention Programme in Physical Education Teacher Education Students: Process Evaluation Using the RE-AIM Sports Setting Matrix.

This study aimed to evaluate the feasibility and effectiveness of an injury prevention programme for Physical Education Teacher Education (PETE) students, consisting of an injury awareness module and implementing prevention strategies during intracurricular lessons. Participants from four PETE programmes formed the intervention group ( = 4 programme directors,  = 38 sports lecturers,  = 859 students), while those from four other programmes were the controls ( = 4 programme directors,  = 34 sports lecturers,  = 721 students). Programme directors and sports lecturers received a three-hour workshop on sports injury prevention.

Magnetic fields reveal signatures of triplet-pair multi-exciton photoluminescence in singlet fission.

The photophysical processes of singlet fission and triplet fusion have numerous emerging applications. They involve the separation of a photo-generated singlet exciton into two dark triplet excitons and the fusion of two dark triplet excitons into an emissive singlet exciton, respectively. The role of the excimer state and the nature of the triplet-pair state in these processes have been a matter of contention.

Singlet fission in TIPS-anthracene thin films.

Singlet fission is an exciton multiplication process that allows for the conversion of one singlet exciton into two triplet excitons. Organic semiconductors, such as acenes and their soluble bis(triisopropylsilylethynyl) (TIPS) substituted counterparts, have played a major role in elucidating the understanding of the underlying mechanisms of singlet fission. Despite this, one prominent member of the acene family that has received little experimental attention to date is TIPS-anthracene, even with computational studies suggesting potential high singlet fission yields in the solid state.

HIV associated neurocognitive disorder screening and diagnosis pathways in Australia: a scoping review and international implications.

Symptomatic HIV-associated neurocognitive disorder (HAND) is a complication of HIV (cognitive impairment, difficulties with everyday functioning). If detected early, interventions assist with optimizing care, avoiding rapid decline and enhancing coping. There remains inconsistency surrounding screening/diagnosis information within Australian healthcare professionals and community settings.

Learning effects in over-ground running gait retraining: A six-month follow-up of a quasi-randomized controlled trial.

This study evaluated learning and recall effects following a feedback-based retraining program. A 6-month follow-up of a quasi-randomized controlled trial was performed with and without recall. Twenty runners were assigned to experimental or control groups and completed a 3-week running program.

Photochemical Upconversion.

Photochemical upconversion is a process whereby two lower-energy photons are converted into a higher-energy photon by sensitized triplet-triplet annihilation. While recent interest in this process has been motivated by improving the efficiencies of solar cells, many applications are being explored. In this review, we address the underlying physicochemical phenomena that are responsible for photochemical upconversion.

Peak Muscle and Joint Contact Forces of Running with Increased Duty Factors.

Purpose: Running with increased duty factors (DF) has been shown to effectively reduce external forces during running. In this study, we investigated whether running with increased DF (INCR) also reduces internal musculoskeletal loading measures, defined as peak muscle forces, muscle force impulses, and peak joint contact forces compared with a runners' preferred running pattern (PREF).

Method: Ten subjects were instructed to run with increased DF at 2.

Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors.

Lung cancer is frequently caused by activating mutations in the epidermal growth factor receptor (EGFR). Allosteric EGFR inhibitors offer promise as the next generation of therapeutics, as they are unaffected by common ATP-site resistance mutations and synergize with the drug osimertinib. Here, we examine combinations of ATP-competitive and allosteric inhibitors to better understand the molecular basis for synergy.

Biomechanical adaptations following a music-based biofeedback gait retraining program to reduce peak tibial accelerations.

Purpose: The present study aimed to determine whether runners can reduce impact measures after a six-session in-the-field gait retraining program with real-time musical biofeedback on axial peak tibial acceleration (PTA ) and identify the associated biomechanical adaptations.

Methods: Twenty trained high-impact runners were assigned to either the biofeedback or the music-only condition. The biofeedback group received real-time feedback on the PTA during the gait retraining program, whereas the music-only condition received a sham treatment.

Foot strike determines the center of pressure behavior and affects impact severity in heel-toe running.

This study assessed the centre of pressure (COP) behaviour and the relationship with impact severity during heel-toe running in conventional athletic footwear. We hypothesized that the COP behaviour depends on its location at foot strike, which would be associated with the vertical loading rate and peak tibial accelerations in heel-toe running. Ground reaction force and tibial acceleration were measured in 104 distance runners running level at ~3.

Reducing the peak tibial acceleration of running by music-based biofeedback: A quasi-randomized controlled trial.

Background: Running retraining with the use of biofeedback on an impact measure has been executed or evaluated in the biomechanics laboratory. Here, the execution and evaluation of feedback-driven retraining are taken out of the laboratory.

Purpose: To determine whether biofeedback can reduce the peak tibial acceleration with or without affecting the running cadence in a 3-week retraining protocol.

Proactive champions: how personal and organizational resources enable proactive personalities to become idea champions.

In investigating the relationship between employees' proactive personality and idea championing, this study addresses how this relationship might be augmented when employees can draw from pertinent personal resources (persuasion self-efficacy and job enthusiasm) and organizational resources (social interaction and organizational support for change). Two-wave survey data, collected among employees in a banking organization, show that employees' proactive personalities increase the likelihood that they mobilize support for innovative ideas, especially if they (1) feel confident that they can defend these ideas successfully, (2) experience their jobs as sources of personal fulfillment, (3) maintain informal relationships with peers, and (4) believe their organizations embrace change. For managers, these findings indicate that employees will leverage their positive energy, derived from their desire for initiative taking, into enhanced change-oriented championing activities if they also can draw from pertinent resources that enhance their ability or motivation to engage in those leveraging efforts.

Redesign of urban biowaste sustainable management system based on industrial ecology concept: A case study in China.

Urban biowaste, which refers to the organic fraction of municipal solid waste (MSW), is a predominant type of waste in low- and middle-income countries. Therefore, the sustainable management of urban biowaste is a key problem in solid waste management (SWM). However, treatment technologies usually come with secondary pollution and by-products that need further treatment, which would limit the economic and environmental benefits of the waste management system.

One hundred marathons in 100 days: Unique biomechanical signature and the evolution of force characteristics and bone density.

Background: An extraordinary long-term running performance may benefit from low dynamic loads and a high load-bearing tolerance. An extraordinary runner (age = 55 years, height = 1.81 m, mass = 92 kg) scheduled a marathon a day for 100 consecutive days.

Relationship between duty factor and external forces in slow recreational runners.

Objectives: Recreational runners show a large interindividual variation in spatiotemporal characteristics. This research focused on slow runners and intended: (1) to document the variance in duty factor (DF) between runners in a real-life running setting and (2) examine whether the interindividual variation in DF and stride frequency (SF) relates to differences in external loading parameters between runners.

Methods: Spatiotemporal characteristics of 23 slow runners (ie, <2.

Traditional high jump Gusimbuka Urukiramende: Could early 20th century African athletes beat Olympic champions?

During the first half of the 20th century, extraordinary high jumping performances of East-African athletes were observed. These athletes used a specific native jumping style called Gusimbuka Urukiramende. Eye-witnesses believed that these performances could have been world-records and that these athletes could have competed at the Olympics.

Taking the Pandemic by Its Horns: Using Work-Related Task Conflict to Transform Perceived Pandemic Threats Into Creativity.

This study investigates a pressing topic, related to the connection between employees' perceptions that the COVID-19 pandemic represents a pertinent threat for their organization on one hand, and their exhibited creativity, a critical behavior through which they can change and improve the organizational status quo, on the other. This connection may depend on their work-related task conflict, or the extent to which they reach out to colleagues to discuss different perspectives on work-related issues, as well as their collectivistic orientation. Data were gathered from employees working in the real estate sector.

Music-based biofeedback to reduce tibial shock in over-ground running: a proof-of-concept study.

Methods to reduce impact in distance runners have been proposed based on real-time auditory feedback of tibial acceleration. These methods were developed using treadmill running. In this study, we extend these methods to a more natural environment with a proof-of-concept.

Impressing for popularity and influence among peers: The connection between employees' upward impression management and peer-rated organizational influence.

To investigate how employees' impression management behavior, targeted upward at organizational leaders, relates to their peer-rated organizational influence, this study considers both a mediating role of peer-rated workplace popularity and a moderating role of self-rated social dominance orientation. Multisource, three-wave data from employees and their peers in the power-distant, collectivistic country of Pakistan reveal that upward impression management behavior, despite raising some potential organizational concerns, is associated with peer-rated workplace popularity for employees, who in turn can wield greater influence over colleagues. The mediating role of peer-rated workplace popularity also is more prominent to the extent that employees accept social hierarchies, because this orientation makes their use of upward impression management tactics to advance their own and their peers' personal interests more purposeful.

Predicting gait events from tibial acceleration in rearfoot running: A structured machine learning approach.

Background: Gait event detection of the initial contact and toe off is essential for running gait analysis, allowing the derivation of parameters such as stance time. Heuristic-based methods exist to estimate these key gait events from tibial accelerometry. However, these methods are tailored to very specific acceleration profiles, which may offer complications when dealing with larger data sets and inherent biological variability.

Suffering doubly: How victims of coworker incivility risk poor performance ratings by responding with organizational deviance, unless they leverage ingratiation skills.

Building on conservation of resources theory, this study investigates the relationship between employees' exposure to coworker incivility and their job performance ratings, while also considering the mediating role of their deviant work behaviors and the moderating role of their ingratiation skills. Results based on multisource, three-wave data from employees and their supervisors in Pakistani organizations show that disrespectful coworker treatment diminishes employees' performance evaluations, because they seek purposefully to cause harm to their employing organization, as a way to vent their frustrations. This mediating role of organizational deviance is mitigated to the extent that employees have a greater ability to ingratiate with others though.

Mutant-Selective Allosteric EGFR Degraders are Effective Against a Broad Range of Drug-Resistant Mutations.

Targeting epidermal growth factor receptor (EGFR) through an allosteric mechanism provides a potential therapeutic strategy to overcome drug-resistant EGFR mutations that emerge within the ATP binding site. Here, we develop an allosteric EGFR degrader, DDC-01-163, which can selectively inhibit the proliferation of L858R/T790M (L/T) mutant Ba/F3 cells while leaving wildtype EGFR Ba/F3 cells unaffected. DDC-01-163 is also effective against osimertinib-resistant cells with L/T/C797S and L/T/L718Q EGFR mutations.