Publications by authors named "Clementine Sallee"
Article Synopsis
- The study analyzes over 3 million genetic variations from the International HapMap Project to identify regions of the human genome that have undergone positive natural selection.
- Using advanced methods, researchers pinpointed over 300 candidate regions, specifically narrowing down to 22 strong areas for further scrutiny.
- The analysis highlights 26 specific gene variations under positive selection, demonstrating similar evolutionary pressures in related genes across different populations, including regions tied to virus infection and traits like skin pigmentation and hair follicle development.
We describe the Phase II HapMap, which characterizes over 3.1 million human single nucleotide polymorphisms (SNPs) genotyped in 270 individuals from four geographically diverse populations and includes 25-35% of common SNP variation in the populations surveyed. The map is estimated to capture untyped common variation with an average maximum r2 of between 0.
View Article and Find Full Text PDFLocus-specific databases (LSDBs) play an essential role in clinical care and research. They differ from traditional genetic databases in that they propose to place the mutations of "anonymized" patients directly on the World Wide Web. The proliferation of ethical guidelines and legal requirements affects the rapid and free transmission of clinical data, which is vital for both the daily management of patients and research into better diagnostics and treatment.
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