Publications by authors named "Clement Triaille"
Unlabelled: Chronic non-bacterial osteomyelitis (CNO) is caused by aseptic inflammation of bones, primarily driven by the innate immune system. CNO may display different clinical presentations (acute vs chronic, uni- vs multifocal) and is accompanied by other inflammatory disorders in up to a third of patients. Once considered a rare disorder, it has become clear that many patients were underdiagnosed.
View Article and Find Full Text PDFUpdate on hereditary C1q deficiency: pathophysiology, clinical presentation, genotype and management.
Curr Opin Allergy Clin Immunol
December 2024
Purpose Of Review: C1q deficiency is a rare inborn error of immunity characterized by susceptibility to severe infections and profound immune dysregulation, with a systemic lupus erythematosus-like phenotype. The management of patients with C1q deficiency is challenged by the rarity of this condition and the wide clinical variability. This review aims to emphasize the importance of a thorough immunological and clinical characterization to help guide a personalized and comprehensive approach to patients.
View Article and Find Full Text PDFArticle Synopsis
- - C1q deficiency is a rare immune disorder that increases the risk of infections and autoimmune diseases similar to systemic lupus erythematosus (SLE), often leading to various health complications.
- - An international study involving 18 patients evaluated the outcomes of hematopoietic stem cell transplantation (HSCT) for C1q deficiency, showing a 71% overall survival rate and improvement in autoimmune symptoms for most patients.
- - The study highlights that patients with severe autoimmune symptoms have poorer survival rates, and specific antibodies were linked to different organ involvements, emphasizing the need for careful patient selection and risk assessment for HSCT as a treatment option.
Article Synopsis
- Hereditary C1q deficiency (C1QDef) is a rare genetic disorder that disrupts the complement system and can cause symptoms similar to systemic lupus erythematosus (SLE).
- A study of 12 genetically confirmed C1QDef patients showed elevated expression of interferon-stimulated genes and high levels of interferon alpha in their blood and cerebrospinal fluid, indicating significant immune dysfunction.
- Treatment with Janus-kinase inhibitors had mixed results, with one patient improving while others continued to struggle with their condition, highlighting the complexity of managing C1QDef.
Objective: Rheumatoid Arthritis (RA) often exhibits suboptimal treatment response despite early diagnosis and treatment. This study aimed to analyze Early Rheumatoid Arthritis (ERA) synovial biopsies through histology and immunohistochemistry (IHC) to identify predictive factors for treatment response to Methotrexate (MTX).
Methods: 140 ERA patients from the UCLouvain Arthritis Cohort underwent synovial biopsy and were monitored after initiating Disease-Modifying Antirheumatic Drug (DMARD) therapy.
Background: Rheumatoid arthritis (RA) is classically considered a systemic disorder, but the role of local factors in driving synovial inflammation is increasingly being recognized. These joint-specific factors may consequently modulate disease phenotype.
Objectives: Our goal was to study the spatial distribution of swelling, tenderness and erosions in a large cohort of early RA (ERA) patients, to assess for patterns of simultaneously-involved joint clusters.
Objective: The objective is to characterize transcriptomic profiles and immune cell composition and distribution in juvenile idiopathic arthritis (JIA) synovial biopsies, assess for associations of these features with clinical parameters, and compare JIA and rheumatoid arthritis (RA) synovial features.
Methods: RNA sequencing (RNASeq) was performed on 24 samples, with pathway analysis and inference of relative abundance of immune cell subsets based on gene expression data. Two multiplex fluorescence immunohistochemistry (IHC) panels were performed on 28 samples (including 13 on which RNASeq was performed), staining for CD206 classical and CD206 nonclassical macrophages, and CD8 and CD4 T and B lymphocytes.
Biologic and targeted synthetic DMARDs (b/tsDMARDs) have revolutionized the management of multiple rheumatic inflammatory conditions. Among these, polyarticular JIA (pJIA) and RA display similarities in terms of disease pathophysiology and response pattern to b/tsDMARDs. Indeed, the therapeutic efficacy of novel targeted drugs is variable among individual patients, in both RA and pJIA.
View Article and Find Full Text PDFObjectives: Transcriptomic profiling of synovial tissue from patients with early, untreated rheumatoid arthritis (RA) was used to explore the ability of unbiased, data-driven approaches to define clinically relevant subgroups.
Methods: RNASeq was performed on 74 samples, with disease activity data collected at inclusion. Principal components analysis (PCA) and unsupervised clustering were used to define patient clusters based on expression of the most variable genes, followed by pathway analysis and inference of relative abundance of immune cell subsets.
Article Synopsis
- The study aimed to evaluate how abatacept affects the synovial tissue in patients with rheumatoid arthritis (RA) and to compare these effects with those of four other disease-modifying antirheumatic drugs (DMARDs).
- Researchers collected synovial tissue samples before and after 16 weeks of abatacept treatment from 14 patients, analyzing cell infiltration and gene expression profiles using advanced techniques and software.
- The findings revealed that abatacept and other DMARDs significantly downregulated genes involved in immune processes, suggesting that these medications may work through similar biological pathways irrespective of their different mechanisms of action.
Objectives: We explored histological and transcriptomic profiles of paired synovial biopsies from rheumatoid arthritis (RA) patients, in order to assess homogeneity in synovial tissue at the individual level.
Methods: Synovial biopsies were performed simultaneously in one small and one large joint per patient using needle-arthroscopy for the knee and ultrasound-guided biopsy for the hand or wrist. Synovium from individuals with osteoarthritis was used as controls.
Synovial Tissue: Turning the Page to Precision Medicine in Arthritis.
Front Med (Lausanne)
March 2019
Article Synopsis
- Rheumatoid arthritis (RA) is a long-term inflammatory disease affecting the joints, with current treatments often failing to achieve early low disease activity in many patients.
- There is a critical need to improve treatment strategies by identifying accurate response markers, with synovial biopsies showing potential for discovering new biomarkers due to their role in disease pathology.
- Variations in the synovial characteristics of RA can influence clinical outcomes and therapy responses, suggesting a path towards personalized medicine by linking specific molecular pathways in the synovium to treatment effectiveness.