Publications by authors named "Clement Carbasse"
Supportive care has become a new pilar of modern oncology, and a great deal of research is being conducted in that area, especially on immune checkpoint inhibitors (ICIs), to help fine-tune immunotherapy. Four major areas of supportive care can enhance responsiveness to cancer immunotherapy whilst minimizing adverse effects: diet (indirectly, by modulating the microbiota or directly, by modulating the immune system), physical activity (by modulating the immune system), electronic patient-reported outcomes (ePRO) (by detecting and treating immune-related adverse events early on), and co-medication management (to possibly suppress those drugs that negatively affect the efficacy of ICIs). Therefore, patients treated with ICIs could receive a systematic multimodal supportive care program encompassing regular nutritional counseling, regular physical activity under the supervision of a physical activity professional, ePRO follow-up, and regular pharmaceutical counseling.
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- The study examines the use of oral targeted therapies (OTTs) for cancer in patients aged 70 and older, highlighting the lack of consensus on appropriate dosing for this demographic.
- At baseline, 29% of older patients had their OTT doses reduced, with those patients being significantly older and having poorer performance status compared to those who received standard doses.
- The findings suggest a need for more clinical studies to assess the safety and effectiveness of dose adaptations for older adults receiving OTTs, given that a considerable number still end up on lower-than-recommended doses during treatment.