Publications by authors named "Clemence Leclerc"
Article Synopsis
- GABAergic interneurons show similar classifications across brain regions, but their distinction in the hilus of the dentate gyrus is uncertain.
- Using patch-clamp techniques and single cell RT-PCR, researchers found that common electrophysiological and molecular traits effectively classify cortical interneurons, but not those in the hilus.
- The study suggests that, although traditional molecular markers are still relevant, hilar interneurons do not have distinct electrophysiological features to support separate classifications.
Article Synopsis
- Adult mammals can generate new neurons and glial cells throughout their lives, with increased neurogenesis linked to better memory performance, particularly in rodents.
- In Alzheimer's disease mouse models, neurogenesis is impaired, leading to cognitive deficits; therefore, boosting neurogenesis could improve hippocampal function.
- The study identified the transcription factor Neurod1, which enhances the generation and integration of new neurons, restoring spatial memory in Alzheimer's mice to levels similar to healthy controls.
