Publications by authors named "Clemence Laperche"
Background-The identification and stratification of patients at risk of fatal outcomes after myocardial infarction (MI) is of considerable interest to guide secondary prevention therapies. Currently, no accurate biomarkers are available to identify subjects who are at risk of suffering acute manifestations of coronary heart disease as well as to predict adverse events after MI. Non-coding circulating microRNAs (miRNAs) have been proposed as novel diagnostic and prognostic biomarkers in cardiovascular diseases.
View Article and Find Full Text PDFBackground: Intravascular lithotripsy (IVL) is a promising new technology for disrupting de-novo calcified coronary lesions (DNL) before percutaneous coronary intervention (PCI). We assessed 12-month outcomes of IVL in patients undergoing PCI for DNL or intra stent restenosis (ISR) lesions related to device underexpansion.
Methods: Prospective analysis of patients in the multicentre all-comers French Shock Initiative IVL registry.
Les lésions calcifiées coronaires ont une incidence croissante dans la pratique quotidienne de l'angioplastie coronaire et sont un des facteurs essentiels des CHIP (High Risk Percutaneous Coronary Intervention). La préparation de la plaque calcifiée est essentielle afin de permettre de bonnes expansion et apposition du stent, deux critères indispensables pour un bon résultat à court et long terme de l'angioplastie coronaire. Depuis 2017, le cathéter C Shockwave Medical® dispose d'un marquage CE pour la préparation des lésions coronaires calcifiées natives avant l'implantation de stent par le mécanisme de lithotripsie intravasculaire.
View Article and Find Full Text PDFObjectives: This study sought to test the superiority in terms of efficacy and safety of a dedicated plug-based vascular closure device (VCD) during transcatheter aortic valve replacement (TAVR) over a suture-based VCD.
Background: Vascular complications after TAVR are relevant and often associated with VCD failure.
Methods: The MASH (MANTA vs.
Objectives: The aim of this study was to describe baseline characteristics, and periprocedural and mid-term outcomes of patients undergoing transcatheter mitral valve interventions post-transcatheter aortic valve replacement (TAVR) and examine their clinical benefit.
Background: The optimal management of residual mitral regurgitation (MR) post-TAVR is challenging.
Methods: This was an international registry of 23 TAVR centers.
Article Synopsis
- The study highlights the need for new biomarkers to better identify high-risk acute coronary syndrome (ACS) patients, focusing on the role of circulating microRNAs (miRNAs) as potential risk indicators.
- In a comparison between ACS patients and control groups, seven miRNAs showed significantly different levels, with five being strongly linked to ACS risk.
- By integrating specific miRNAs into existing predictive models, the study improved risk assessment accuracy, increasing the predictive performance from an area under the curve (AUC) of 0.882 to 0.924.
Background: International guidelines recommend that preoperative coronary angiography is performed on patients at risk of coronary disease who have infective endocarditis requiring surgical treatment. However, the risks of contrast-induced nephropathy or vegetation embolization in case of aortic endocarditis should be considered.
Aims: To assess the safety, therapeutic implications and prognostic impact of coronary angiography in patients requiring surgical treatment for active infective endocarditis.