Building Process Understanding of Fluid Bed Taste Mask Coating of Microspheres.

Taste is routinely cited as one of the major contributing factors that negatively influence pediatric patient compliance. A promising solution is coated microsphere systems, which provide doses of active pharmaceutical ingredients (API) subdivided into a plurality of small dosage units. In this work, the microspheres were coated with Kollicoat® Smartseal, a reverse enteric polymer, which acts to minimize or prevent the release of API in the neutral pH of the oral cavity, which results in a masking effect of the unpleasant taste of the API.

A Hierarchical Multivariate Curve Resolution Methodology To Identify and Map Compounds in Spectral Images.

The use of spectroscopic methods, such as near-infrared or Raman, for quality control applications combined with the constant search for finer details leads to the acquisition of increasingly complex data sets. This should not prevent the user from characterizing a sample by identifying and mapping its chemical compounds. Multivariate data analysis methods make it possible to obtain qualitative and quantitative information from such data sets.

Specificity of process analytical tools in the monitoring of multicomponent pharmaceutical powders.

The application of Process Analytical Technologies in pharmaceutical manufacturing has been the subject of many studies. Active pharmaceutical ingredient monitoring in real time throughout the manufacturing process is commonly the target of many such implementations. The tools in place must be sensitive to, and selective of, the parameter(s) to be monitored, i.

Using multiple Process Analytical Technology probes to monitor multivitamin blends in a tableting feed frame.

As Process Analytical Technology (PAT) implementation grows in the pharmaceutical industry, more studies are being performed to evaluate its suitability in new applications and processes within the manufacturing chain. As the last step in tablet production, the compression stage represents a critical phase that ensures product quality. In-line control put in place at this stage has the potential to detect powder blends that are out of specification limits and, thus, help to improve product quality.