Publications by authors named "Clemence Demerle"
Article Synopsis
- In patients with acute myeloid leukemia (AML), a higher presence of Vγ9Vδ2 T cells at diagnosis is associated with better overall and relapse-free survival rates.
- This study analyzed immunophenotypic data from 198 newly diagnosed AML patients to determine how Vγ9Vδ2 T-cell frequency impacts prognosis while adjusting for various confounding factors.
- The findings support the importance of Vγ9Vδ2 T cells in AML prognosis and suggest potential treatment strategies that could boost these T-cell responses in patients.
Article Synopsis
- TNFRSF14/HVEM is linked to immune response regulation and tumor progression, with its overexpression correlating to poorer prognosis in cancer patients.
- Researchers developed mouse models that mimic human BTLA and HVEM interactions to study the effects of a specific antibody (anti-HVEM18-10) on T cell activity in cancer environments.
- The findings indicate that anti-HVEM18-10 enhances T cell responses against tumors, decreases the presence of exhausted T cells, and leads to lasting tumor immunity, suggesting its potential as a therapeutic option in cancer treatment.
Background: Transfusion of defective platelets could contribute to the inefficiency of platelet transfusion in preventing or stopping bleeding.
Study Design And Methods: This single-center prospective study aimed to determine the prevalence of functional platelet abnormalities in a population of blood donors with a clinical history of bleeding diathesis or with history of hematoma (>4 cm) during blood donation. Donors with positive bleeding screening questionnaire were referred to the reference center for rare platelet diseases at La Timone University Hospital (Marseille) to confirm the bleeding tendency using a more extensive bleeding questionnaire (MCMDMscore) and to assess hemostasis, including a comprehensive platelet analysis.
Lung cancer is the leading cause of cancer deaths worldwide. Immunotherapies (IT) have been rapidly approved for lung cancer treatment after the spectacular results in melanoma. Responses to the currently used checkpoint inhibitors are strikingly good especially in metastatic diseases.
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- Natural killer (NK) cells are crucial in fighting leukemia, but their function is hindered by leukemic blasts, leading to the presence of dysfunctional NK cells in acute myeloid leukemia (AML).
- In a study involving patients with newly diagnosed AML, researchers found a significant accumulation of a specific subset of NK cells (CD56CD16) that resemble those seen in HIV-infected individuals, indicating a potential disruption in their activation and function.
- A higher percentage of these CD56CD16 NK cells at diagnosis correlated with poorer clinical outcomes, suggesting they might be a marker for immune evasion as AML progresses.
Septic shock, a major cause of death in critical care, is the clinical translation of a cytokine storm in response to infection. It can be complicated by sepsis-induced immunosuppression, exemplified by blood lymphopenia, an excess of circulating Treg lymphocytes, and decreased HLA-DR expression on circulating monocytes. Such immunosuppression is associated with secondary infections, and higher mortality.
View Article and Find Full Text PDFChronic hepatitis E in absence of severe immune deficiency.
Clin Res Hepatol Gastroenterol
February 2020
Article Synopsis
- Researchers are finding that natural killer (NK) cells, which help fight cancer, can help predict how well cancer patients will do, making them important for new treatments.
- In a study of 87 patients with a type of blood cancer called acute myeloid leukemia, three groups of NK cell maturity were identified: hypomaturation (not mature), intermediate, and hypermaturation (very mature).
- Patients with hypomaturation had much worse survival rates compared to those with intermediate or hypermaturation, highlighting how important NK cell maturity is for cancer outcomes.
Cytogenetics and European Leukemia Net (ELN) genetic classification predict patients at increased risk of relapse in acute myeloid leukemia (AML) except in the intermediate risk group for which further prognostic determinants are required. We have previously shown that Natural Killer (NK) cell defects in AML are predictors of poor overall survival (OS). This study aimins at validating NKp30, a receptor that mediates NK activation, as a prognostic biomarker for AML patients with intermediate prognosis.
View Article and Find Full Text PDFIntroduction: Community-acquired meningitis is a monomicrobial infection caused by either viruses or bacteria in the vast majority of patients. We report here one exceptional case of a patient with mixed bacterial meningitis due to Streptococcus pneumoniae and Streptococcus pyogenes.
Case Presentation: We report the case of a 68-year-old immunocompromised Caucasian man suffering from otitis and then meningitis caused by Streptococcus pneumoniae and Streptococcus pyogenes.