Evaluation of the uptake and delivery of the NHS Health Check programme in England, using primary care data from 9.5 million people: a cross-sectional study.

Objectives: To describe the uptake and outputs of the National Health Service Health Check (NHSHC) programme in England.

Design: Observational study.

Setting: National primary care data extracted directly by NHS Digital from 90% of general practices (GP) in England.

Long-term follow-up of the incisional hernia rate after single-incision laparoscopic cholecystectomy: a prospective observational study.

Purpose: To evaluate the long-term occurrence rate of incisional hernias following single-incision laparoscopic cholecystectomy (SILC).

Background: Since the 90 s, SILC has emerged as a less invasive alternative to standard laparoscopic cholecystectomy in selected patients. But concerns over port-incisional hernias have not been addressed.

Consumption of Health-Related Content on Social Media Among Adolescent Girls: Mixed-Methods Pilot Study.

Background: Consumption of health- and fitness-related social media content is a predominant behavior among teenage girls, which puts them at risk for consuming unreliable health-related information.

Objective: This mixed-methods study (qualitative and quantitative) assessed health behavior attitudes and practices as well as social media use among adolescent girls. Additionally, similar practices and behaviors of adults who regularly interact with this population were studied.

Choice Architecture in Appalachian High Schools: Evaluating and Improving Cafeteria Environments.

School meals are a primary source of nutrition for many adolescents. Determining factors that influence the selection of various foods can provide insight on strategies to improve students' cafeteria choices. This evaluation and observation was conducted at three Appalachian high schools to assess the cafeteria environment.

KATALYST: Development of a 5 grade novel approach to health and science experiential learning.

The Katalyst intervention program was piloted in fifth-grade classrooms at two Appalachian schools during the 2017-18 academic year as a potential educational resource to tackle the rising rates of obesity and chronic diseases in this region. The program consisted of four 60-minute modules, each based on a specific organ system. Each module incorporated hands-on lessons in physiology with an emphasis on preventing chronic disease through diet, nutrition, physical activity, and abstinence from drug and tobacco use.

Unusual upward closed tibiotalar dislocation without fracture: A case report.

Pure tibiotalar dislocations without associated fracture are rare. The authors report a case of an unusual closed tibiotalar dislocation without fracture, involving proximal ascension of the talus. Despite immediate closed reduction, a tibiofibular diastasis remained, therefore two syndesmosis screws were inserted, followed by six weeks of plaster casting.

A novel amphibian tier 2 testing protocol: a 30-week exposure of Xenopus tropicalis to the antiandrogen flutamide.

In 1996, the U.S. Congress mandated the development of a screening program for endocrine-disrupting chemicals (EDCs) using validated test systems.

Infectious disease mortality in two Outer Hebridean islands: 2. pulmonary tuberculosis.

Objective: To examine mortality from pulmonary tuberculosis (PTB) in the Outer Hebridean islands of Harris and Barra, and to compare it with that in Scotland as a whole.

Design: Ages and dates of death from PTB in Harris and Barra between 1855 and 1990 were ascertained from copies of death certificates. For Scotland, annual numbers of deaths in 5-year age-groups were extracted from Annual Reports of the Registrars General.

Infectious disease mortality in two Outer Hebridean islands: 1. measles, pertussis and influenza.

Objectives: The purpose of the study was to examine changes in mortality from measles, pertussis (whooping cough) and influenza (all epidemic diseases) in Harris and Barra, two Outer Hebridean islands, from 1855 to 1990, and to compare the findings with those from Scotland as a whole over the same period. It was also intended to relate changes in mortality to those in social and economic factors.

Materials And Methods: Ages and causes of death in Harris and Barra were ascertained from copies of death certificates held at the General Register Office, Edinburgh, and for Scotland as a whole from the Annual Reports of the Registrars General for Scotland.

Relationship between sperm characteristics and hormonal parameters in normal couples.

Objective: To examine the relationships between hormone profiles and semen analysis measures and fertility in the male partners of presumed normal couples.

Design: Prospective clinical study.

Settings: Healthy volunteers in an academic research environment.

Starting, spacing and stopping in the reproductive histories of outer Hebridean families.

Maternal ages at the first maternity (starting), at the last maternity (stopping) and the lengths of intervals between maternities (spacing) have been studied in the Outer Hebridean islands of Harris and Barra for births between the years of 1855 and 1990, a period during which a considerable 'fertility transition' occurred. There was a tendency in each island for increases with time in the ages at starting among less-fecund women (although after 1936 starting ages declined), and highly significant heterogeneity of covariance: adjusted means dependent on the total numbers of maternities experienced. The same result was seen for the ages at stopping.

Semen quality and human fertility: a prospective study with healthy couples.

Measures of semen quality are used as surrogate measures of male fertility in clinical andrology, reproductive toxicology, epidemiology, and risk assessment. However, only limited data are available to relate those measures to fertility. This prospective study with 210 reproductive-age couples was conducted to provide information on the value of semen quality measures for predicting human male fertility potential and for development of models to estimate the effects of changes in semen quality on fertility in a given population for risk assessment.

Probabilities of marriage in two outer Hebridean islands, 1861-1990.

A study has been made of the probabilities of marriage of females and males aged 15-49 (either as a whole or in 5-year age groups) in two Outer Hebridean islands, Harris and Barra. The results were compared with ages of marriage and with the frequencies of permanent celibacy. The marriages took place between 1861 and 1990.

Utility of the sperm chromatin structure assay as a diagnostic and prognostic tool in the human fertility clinic.

The sperm chromatin structure assay (SCSA) was used to measure over 500 human semen samples from two independent studies: Study I, 402 samples from 165 presumably fertile couples wishing to achieve pregnancy over 12 menstrual cycles; Study II, samples from 115 patients seeking fertility counselling. The SCSA measures susceptibility to DNA denaturation in situ in spermatozoa exposed to acid for 30 s, followed by acridine orange staining. SCSA data from the male partners of 73 couples (group 1) achieving pregnancy during months 1-3 of Study I were used as the standard of 'sperm chromatin compatible with high fertility' and were significantly different from those of 40 couples (group 3) achieving pregnancy in months 4-12 (P < 0.

Some factors affecting marital distances in the Outer Hebrides.

Some factors affecting marital distances have been studied in two Outer Hebridean islands, Harris (843 marriages) and Barra (444 marriages), over the period 1855-1990. In each island marital distances fell before 1900, but then rose to their greatest values after the 1950s. Fisherman generally married at the shortest distances and men in land-based occupations at the longest.

Environmental endocrine disruption: an effects assessment and analysis.

This report is an overview of the current state of the science relative to environmental endocrine disruption in humans, laboratory testing, and wildlife species. Background information is presented on the field of endocrinology, the nature of hormones, and potential sites for endocrine disruption, with specific examples of chemicals affecting these sites. An attempt is made to present objectively the issue of endocrine disruption, consider working hypotheses, offer opposing viewpoints, analyze the available information, and provide a reasonable assessment of the problem.

Leydig cell hyperplasia and adenoma formation: mechanisms and relevance to humans.

Leydig cell adenomas are observed frequently in studies evaluating the chronic toxicity of chemical agents in laboratory animals. Doubts have been raised about the relevance of such responses for human risk assessment, but the question of relevance has not been evaluated and presented in a comprehensive manner by a broad group of experts. This article reports the consensus conclusions from a workshop on rodent Leydig cell adenomas and human relevance.

The relationship of the postcoital test and semen characteristics to pregnancy rates in 200 presumed fertile couples.

Objective: To evaluate the postcoital test (PCT) and semen analysis (SA) in the prediction of pregnancy in 200 potentially fertile couples.

Methods: 200 couples without risk for infertility were prospectively followed for 1 year. Couples were attempting pregnancy for 12 menstrual cycles.

Evaluation of computer-assisted semen analysis (CASA) with IDENT stain to determine sperm concentration.

This study was undertaken to compare a new fluorescent stain-based computer-assisted semen analysis (CASA) system (IDENT) for determining human sperm concentration to the manual hemacytometric method and to conventional CASA (CASA-CONV). Normal healthy semen donors as well as patients provided samples that were evaluated for sperm concentration with the CASA-IDENT method, the hemacytometer method, and CASA-CONV. Each field was examined visually to determine the sources of overcounting and undercounting for the two CASA methods.

Methods for assessing sperm motility, morphology, and counts in the rat, rabbit, and dog: a consensus report. ILSI Risk Science Institute Expert Working Group on Sperm Evaluation.

Reproductive toxicity studies are increasingly including assessments of sperm parameters including motility, morphology, and counts. While these assessments can provide valuable information for the determination of potential reproductive toxicity, the methods for conducting the assessments have not been well developed in all laboratories and are continually evolving. The use of different methods in different laboratories makes comparison of data among laboratories difficult.

Estimates of human fertility and pregnancy loss.

Objective: To examine the fertility and pregnancy wastage rates in a group of presumably fertile couples.

Design: Prospective observational study of 200 couples desiring to achieve pregnancy over 12 menstrual cycles coupled with pregnancy outcome follow-up.

Setting: A university-based obstetrics and gynecological center.

Religion and fertility in the Outer Hebrides.

Estimates of fertility in Protestant Barra and Catholic Harris, islands in the Outer Hebrides, over the period 1856-1985, show that in both islands fertility declined, although marital fertility was generally greater than in Scotland as a whole, and illegitimate fertility was less. However, in Barra during 1966-75 there were pronounced rises in all the indices; illegitimate fertility showed the smallest rise. The publication of the papal encyclical Humanae Vitae may have played a part in this change in fertility, although other, probably local, factors must have been acting, as the first rise in numbers of births occurred before the publication of the encyclical.

Subcutaneous infusion ports in the pediatric patient with hemophilia.

Central venous access devices have become important tools in the management of pediatric patients with malnutrition, malignancy, and infections requiring long-term antibiotic treatment. Hemophilia presents a lifetime challenge for venous access and at times can be an urgent or life-threatening situation. Since 1986, the authors have implanted 11 subcutaneous infusion ports in nine patients with hemophilia.

Aspects of neonatal death in St Kilda, 1830-1930.

Neonatal death (mainly due to tetanus) was common in St Kilda until 1891. Two aspects of this phenomenon are studied; factors which predicted death, and the impact of neonatal death on family building. Maternal age appeared to be a predictive factor for death of the first child, but only in children of high birth order were other factors, particularly the number of previous neonatal deaths, important.