Sexual Motivation and Sexual Reward in Male Rats are Attenuated by the Gonadotropin-Releasing Hormone Receptor Antagonist Degarelix.

Background: Preclinical studies that have examined the effects of androgen deprivation therapies (ADTs) on sexual outcomes have either relied on a surgical castration model of ADTs or have largely focused on consummatory sexual behaviors.

Aim: The aim of this study was to examine the effects of a single administration of the gonadotropin-releasing hormone receptor antagonist, degarelix, on sexual incentive motivation (SIM), sexual reward, consummatory sexual behaviors, anxiety-like behavior, and androgen receptor signaling in male rats, and to determine if sexual stimulation attenuates the effects of degarelix on SIM.

Methods: Male rats were treated with degarelix, or vehicle, and half of the rats in each condition were briefly exposed to a sexually receptive female immediately before SIM trials (experiment 1).

Self-assembled thermoreversible gels of nonpolar liquids by racemic propargylic alcohols with fluorinated and nonfluorinated aromatic rings.

The synthesis and colloidal study of a new class of low molecular weight organogelators is reported. Racemic propargylic alcohols with perfluoroaryl and nonfluorinated aryl rings are capable of forming gels in alkane liquids and/or silicone oil. A full colloidal characterization of alkane gels prepared from (R/S)-1-pentafluorophenyl-3-phenylprop-2-yn-1-ol [(R/S)- 1] was conducted, including both structural [optical microscopy, scanning electron microscopy (SEM), powder X-ray diffraction (XRD), attenuated total reflectance infrared spectroscopy (ATR-IR)] and thermal stability [differential scanning calorimetry (DSC)] studies.