Publications by Clay P Page

Publications by authors named "Clay P Page"

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Prevention of Protease-Induced Degradation of Desmoplakin via Small Molecule Binding.

Isabel M Romov Roujon A Nowzari Clay P Page Madeleine R Benes Maegen A Borzok

J Pers Med

January 2024

Desmoplakin (DSP) is a large (~260 kDa) protein found in the desmosome, the subcellular structure that links the intermediate filament network of one cell to its neighbor. A mutation "hot-spot" within the NH-terminal of the DSP protein (residues 299-515) is associated with arrhythmogenic cardiomyopathy. In a subset of variants, disease is linked to calpain hypersensitivity.

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