Publications by authors named "Clay Bavinger"
Purpose: To report a case of severe retinal ischemia in an infant with neurofibromatosis type 1.
Methods: Chart review, analysis of imaging studies, and review of literature.
Results: A boy born at 37 weeks postmenstrual age with neurofibromatosis type 1 was noted to have a large plexiform neurofibroma with left-sided involvement of the cavernous sinus, internal carotid artery, orbit, and optic nerve.
Importance: Diabetic retinopathy (DR) may progress from nonproliferative DR (NPDR) to vision-threatening DR (VTDR). Studies have investigated fenofibrate use as a protective measure with conflicting results, and fenofibrate is not typically considered by ophthalmologists in the management of DR currently.
Objective: To assess the association between fenofibrate use and the progression from NPDR to VTDR, proliferative DR (PDR), or diabetic macular edema (DME).
Statin use and the risk of progression to vision threatening diabetic retinopathy.
Pharmacoepidemiol Drug Saf
June 2022
Article Synopsis
- The study investigates the impact of statins on the progression of nonproliferative diabetic retinopathy (NPDR) to more severe forms like vision-threatening diabetic retinopathy (VTDR), proliferative diabetic retinopathy (PDR), or diabetic macular edema (DME).
- Using data from a U.S. medical claims database, researchers conducted two cohort studies comparing statin users and non-users; they failed to find any protective effects of statins against DR progression.
- The findings suggest that factors related to the population studied are more critical than the study methodology in understanding the relationship between statin use and diabetic retinopathy progression.
Purpose: Retinal detachment (RD) is associated with poor visual outcomes in patients with acute retinal necrosis (ARN). This research was undertaken to assess the risk factors for RD in ARN.
Design: Retrospective cohort study.
Purpose: To describe the visual acuity and anatomic outcomes of intravitreal methotrexate (MTX) for the treatment of primary vitreoretinal lymphoma (PVRL).
Methods: Single-center retrospective case series of patients with a diagnosis of PVRL treated with intravitreal MTX. Patient records were reviewed for demographic information, ocular exam findings, and treatment regimens including number of MTX injections.
Article Synopsis
- The case study discusses a 54-year-old woman with Rosai-Dorfman Disease (RDD), which is a condition that causes an overgrowth of certain immune cells and often involves swollen lymph nodes and rare eye issues.
- She developed bilateral panuveitis (inflammation of the eye) and choroidal masses, which initially improved with steroids but later progressed, leading to the switch to pegylated interferon for treatment.
- After 14 months on pegylated interferon, both her systemic and ocular symptoms stabilized, highlighting the need for a team-based approach to manage the complex nature of RDD.
Acute retinal necrosis (ARN) is a devastating syndrome characterized by panuveitis, retinal necrosis, and a high rate of retinal detachment that may result in poor visual outcomes if not promptly diagnosed and treated. ARN is most commonly caused by viruses with the herpesvirus family. Etiologies include varicella-zoster virus, herpes simplex virus, and cytomegalovirus, and may be promptly diagnosed by polymerase chain reaction testing of aqueous or vitreous fluid.
View Article and Find Full Text PDFEbola, COVID-19, and emerging infectious disease: lessons learned and future preparedness.
Curr Opin Ophthalmol
September 2020
Purpose Of Review: To highlight the lessons learned from the Ebola outbreak that may inform our approach to the COVID-19 pandemic, particularly related to the widespread disruption of healthcare, ophthalmic disease manifestations, and vision health systems strengthening for future outbreaks.
Recent Findings: Coronavirus disease 2019 (COVID-19), first detected in China in December 2019, has become a worldwide health emergency, with significant disruption of all aspects of society, including travel, business, and medical care. Although this pandemic has had unprecedented effects on healthcare delivery in the United States, experiences from recent Ebola virus disease (EVD) outbreaks in Africa provide insight and inform our approach to COVID-19 and outbreak preparedness.
Ebola virus disease (EVD) and emerging infectious disease threats continue to threaten life, prosperity and global health security. To properly counteract EVD, an improved understanding of the long-term impact of recent EVD outbreaks in West Africa and the Democratic Republic of Congo are needed. In the wake of recent outbreaks, numerous health sequelae were identified in EVD survivors.
View Article and Find Full Text PDFImportance: Recent reports suggest that cilioretinal arteries (CRAs) confer protection against developing advanced age-related macular degeneration (AMD).
Objective: To further characterize the association between the presence of a CRA and incidence of geographic atrophy (GA) or choroidal neovascularization (CNV).
Design: This cohort study constituted an ad hoc secondary analysis of data from the Comparison of Age-Related Macular Degeneration Treatments Trials (CATT) and was performed at 44 clinical centers in the United States among participants in CATT with CNV in the study eye and without advanced AMD in the fellow eye at baseline.
Purpose: To determine whether sterile preloading of anti-vascular endothelial growth factor agents reduces the risk of postintravitreal injection endophthalmitis.
Methods: This is a retrospective cohort study using medical claims data from a large, national US insurer. Cohorts were created using intravitreal injections of anti-vascular endothelial growth factor injections from 2005 to 2016.
The relationship between burden of childhood disease and foreign aid for child health.
BMC Health Serv Res
September 2017
Background: We sought to examine the relationship between child specific health aid (CHA) and burden of disease. Based on existing evidence, we hypothesized that foreign aid for child health would not be proportional to burden of disease.
Methods: In order to examine CHA and burden of disease, we obtained estimates of these parameters from established sources.
Introduction We compared remote, image-based patient consultations to in-person consultations at emergency department and inpatient hospital settings. Methods Patients evaluated by the ophthalmic consultation services (gold standard) were imaged over a two-week period. A trained study coordinator took anterior segment photographs (AS) and posterior segment photographs (PS) with a portable camera (PictorPlus, Volk Optical, Cleveland, OH).
View Article and Find Full Text PDFPurpose: The pathophysiology of vision loss in persons with diabetic retinopathy (DR) is complex and incompletely defined. We hypothesized that retinal pigment epithelium (RPE) and rod and cone photoreceptor dysfunction, as measured by dark adaptometry, would increase with severity of DR, and that pan-retinal photocoagulation (PRP) would exacerbate this dysfunction.
Methods: Dark adaptation (DA) was measured in subjects with diabetes mellitus and healthy controls.
Purpose Of Review: Dry eye syndrome can be difficult to manage in severe or refractory cases. In patients in whom traditional treatments have limited efficacy, alternative treatments may be considered for dry eye syndrome, including scleral lenses. The present review summarizes the evidence regarding scleral lens use in dry eye syndrome.
View Article and Find Full Text PDFBackground: Recent studies suggest certain antiretroviral therapy (ART) drugs are associated with increases in cardiovascular disease.
Purpose: We performed a systematic review and meta-analysis to summarize the available evidence, with the goal of elucidating whether specific ART drugs are associated with an increased risk of myocardial infarction (MI).
Data Sources: We searched Medline, Web of Science, the Cochrane Library, and abstract archives from the Conference on Retroviruses and Opportunistic Infections and International AIDS Society up to June 2011 to identify published articles and abstracts.
Background: The health benefits of organic foods are unclear.
Purpose: To review evidence comparing the health effects of organic and conventional foods.
Data Sources: MEDLINE (January 1966 to May 2011), EMBASE, CAB Direct, Agricola, TOXNET, Cochrane Library (January 1966 to May 2009), and bibliographies of retrieved articles.