Identification of characteristics and frequent scenarios of single-vehicle rollover crashes during pre-ballistic phase; part 1 - A descriptive study.

This study aimed to identify common patterns of pre-ballistic vehicle kinematics and roadway characteristics of real-world rollover crashes. Rollover crashes that were enrolled in the National Automotive Sampling System-Crashworthiness Data System (NASS-CDS) between the years 2000 and 2010 were analyzed. A descriptive analysis was performed to understand the characteristics of the pre-ballistic phase.

Constrained Laboratory vs. Unconstrained Steering-Induced Rollover Crash Tests.

Objective: The goal of this study was to evaluate how well an in-laboratory rollover crash test methodology that constrains vehicle motion can reproduce the dynamics of unconstrained full-scale steering-induced rollover crash tests in sand.

Methods: Data from previously-published unconstrained steering-induced rollover crash tests using a full-size pickup and mid-sized sedan were analyzed to determine vehicle-to-ground impact conditions and kinematic response of the vehicles throughout the tests. Then, a pair of replicate vehicles were prepared to match the inertial properties of the steering-induced test vehicles and configured to record dynamic roof structure deformations and kinematic response.

Natural daucane esters induces apoptosis in leukaemic cells through ROS production.

Continuing our research on antiproliferative agents from plants, we extended our interest on further compounds isolated from Ferula communis and Ferulago campestris. One new daucane (DE-20) and one new phenol derivative (PH-3) were isolated and characterized in addition to six daucane, three coumarins and four simple phenolics. The cytotoxic activity was evaluated against a panel of six human tumor cell lines.

Changes in urinary metabolic profile after oral administration of curcuma extract in rats.

The diffusion of phytochemicals in health promoting products is growing, but studies related to their effects on healthy subjects are still lacking despite the large consumption of natural products as nutraceuticals or food supplements. In many cases, research supports the in vitro antioxidant activity of phytochemicals, but the health claims attributed to the final marketed nutraceutical products have dubious scientific foundation. Also, studies focussed on the definition of their biological targets and mechanisms of action can be useful to assess their efficacy and safety.

Differences in the chemical composition of Arnica montana flowers from wild populations of north Italy.

The flower heads of fourteen wild Arnica montana L. populations were collected in the summer of 2010 in the provinces of Trento, Brescia and Bergamo (Italy). The dried flowers were analyzed to assess their chemical diversity.

[Obesity and cardiac cachexia in chronic heart failure].

Obesity as well as cardiac cachexia in heart failure patients are not fully understood and therefore of high scientific interest. Obesity as a common risk factor for cardiovascular disease is associated with a high mortality. In contrast obesity in patients suffering from chronic heart failure seems to be accompanied with a favorable outcome in contrast to people with normal weight, known as the obesity paradox.

Phytochemical investigation on Atriplex halimus L. from Sardinia.

In this study, we reported the phytochemical composition of the aerial parts of Atriplex halimus L. collected from Sardinia. This species is a halophytic shrub, typical of the Mediterranean Basin.

[Preoperative staging of rectal carcinoma by transrectal echography combined with pelvic computerized tomography].

The accurate staging of rectal carcinoma is very important for treatment planning. The histological data obtained from the surgical specimens of 22 patients with rectal carcinoma were compared with pre- and postoperative endorectal US findings and with preoperative CT results. According to an adapted version of the Astler and Coller classification, the different degrees of tumor spread into the rectal wall were represented as follows: stage A: 1 patient; stage B1: 5 patients; stage B2: 6 patients; stage C1: 1 patient; stage C2: 8 patients and stage D: 1 patient.

Synthesis of 3-(1,3,4-thiadiazol-2-yl)pyrazolo[1,5-a] pyrimidine derivatives as potential antimicrobial agents.

The synthesis of some 3-(1,3,4-thiadiazol-2-yl)pyrazolo[1,5-a]-pyrimidine derivatives is performed by reacting 2-(3-amino-1,2-dihydro-5-oxo-5H-pyrazol-4-il)-1,3,4- thiadiazoles with 2,4-pentanedione, ethyl 3-oxobutyrate and diethyl ethoxymethylenemalonate. The antimicrobial activity of the synthesized compounds is reported.

Synthesis of 2-[1,2-dihydropyrazol-4-yl]-1,3,4-thiadiazole derivatives as potential antimicrobial agents.

The synthesis of some 2-[1,2-dihydropyrazol-4-yl]-1,3,4-thiadiazole derivatives is performed by reacting 4-dithiocarboxylic acid hydrazides of 3-amino-1,2-dihydro-5H-pyrazol-5-one and 3-amino-1,2-dihydro-1-methyl-5H-pyrazol-5-one with carboxylic acid derivatives. The unusual behaviour of 3-amino-1,2-dihydro-1-methyl-5H-pyrazol-5-one towards acetylating agents is described. The antimicrobial activity of some 2-[1,2-dihydropyrazol-4-yl]-1,3,4-thiadiazole derivatives is tested in a preliminary screening.

[Studies of myocardial metabolism using P-31-NMR spectroscopy and a simple heart perfusion model of slaughtered animals--an approach to avoiding in vivo animal experiments].

In research cardiology large numbers of in vivo animal experiments, mostly with dogs or pigs, are necessary. It was the aim of this study to test a simple in vitro perfusion heart model from swine harvested in the slaughterhouse as a potential substitute for in vivo animal studies. 32 unselected hearts of slaughterhouse swine after 10 to 15 min of warm ischemia were subjected to reperfusion with warm oxygenized blood and were examined for mechanical recovery, which occurred in 56%, increasing to 95% if primarily using only hearts that were in relaxation.

[Some derivatives of the 2-[4-pyrazolinyl]-1,3,4-thiadiazole system].

The synthesis of some 2-[5-amino-1-methyl-3-oxo-4-pyrazolynyl]-1,3,4-thiadiazole derivatives is accomplished by reacting 5-amino-1-methyl-3-oxopryrazolynyl-4-dithiocarbohydrazide with carboxylic acid derivatives. The structure of the compounds obtained is verified by means of 1H and 13C-N.M.

[Xeroradiography in nasal bones fractures (author's transl)].

Traumatic lesions of nasal bones were investigated by xerography in 44 patients. "Negative", rather than "positive", method is preferred. Soft tissues can be accurately inspected too; these lesions can exactly evaluated and possible contraindications to surgical reduction of such fractures are easily detected.