Publications by authors named "Claus Weidemeyer"
Towards new antimalarial drugs: synthesis of non-hydrolyzable phosphate mimics as feed for a predictive QSAR study on 1-deoxy-D-xylulose-5-phosphate reductoisomerase inhibitors.
Dirk Giessmann Philipp Heidler Timothy Haemers Serge Van Calenbergh Armin Reichenberg Claus Weidemeyer
Chem Biodivers
April 2008
Article Synopsis
- The conversion of DOXP to MEP is effectively inhibited by Dxr inhibitors like fosmidomycin, which is a natural antibiotic.
- To predict how closely related compounds bind to Dxr, researchers are synthesizing various fosmidomycin derivatives to improve target affinity.
- They have created a range of phosphonic acids that show inhibitory activity against E. coli and P. falciparum Dxr, with IC(50) values varying between 1 to over 30 microM.