Tibolone and its metabolites acutely relax rabbit coronary arteries in vitro.

Objectives: To compare the acute effects of estradiol, tibolone and its metabolites on coronary arteries in vitro and to investigate possible vascular mechanisms.

Methods: Coronary artery ring segments from female rabbits were mounted in myographs for isometric tension recordings. Concentration-response curves to tibolone, 3 alpha-OH-tibolone, 3 beta-OH-tibolone, Delta 4-isomer and 17 beta-estradiol were obtained after precontraction with potassium 30 mmol/l and after addition of N omega-nitro-l-arginine methyl ester 10(-4) mol/l (l-NAME, an inhibitor of endothelial nitric oxide (NO) synthase) or tetraethylammonium chloride 10(-2) mol/l (TEA, an unspecific inhibitor of potassium channels).

Improved fertility following conservative surgical treatment of ectopic pregnancy.

Objective: To evaluate fertility after salpingectomy or tubotomy for ectopic pregnancy.

Design: Retrospective cohort study.

Setting: Clinical University Center, Hvidovre Hospital, Copenhagen.

Persistent ectopic pregnancy after linear salpingotomy: a non-predictable complication to conservative surgery for tubal gestation.

Background: The drawback of conservative surgery for ectopic pregnancy (EP) is the risk of persistent trophoblast. The purpose was to characterize patients who develop persistent ectopic pregnancy (PEP) after salpingotomy for EP and to assess prognostic factors.

Methods: The medical records of 417 patients treated by salpingotomy for EP were reviewed.