Publications by authors named "Claudius Kruse"
Article Synopsis
- Intestinal preservation for transplantation often involves long periods of ischemia that can cause structural damage due to lack of blood and oxygen supply.
- This study tested a method of delivering intraluminal oxygen during warm ischemia in a pig model to see if it could prevent ischemic damage.
- Results showed that the pigs receiving intraluminal oxygen had better mucosal integrity and overall viability compared to the control group, suggesting it could enhance methods for preserving the intestine for transplantation.
Hemodynamic support of patients with septic shock is often complicated by a tachyphylaxis against exogenous catecholamines. Because an increase in somatotropic hormones may play a pivotal role in the regulation of the inflammatory response to endotoxin, intravenous supplementation of the neuroendocrine hormone somatostatin (SOMA) may attenuate hemodynamic dysfunction resulting from endotoxemia. The objective of the present study was to assess the short-term effects of SOMA alone and in combination with norepinephrine (NE) on cardiopulmonary hemodynamics, global oxygen transport, plasma nitrate/nitrite levels, and intestinal integrity compared with single NE therapy in ovine endotoxemia.
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