Publications by authors named "Claudius Conrads"
Article Synopsis
- Oxidative stress plays a role in osteoarthritis, with the Nrf2/ARE pathway being crucial for maintaining redox balance and regulating SOX9 expression in chondrocytes.
- Researchers utilized shRNA to manipulate Nrf2 and Keap1 levels in human chondrocytes and conducted dual-luciferase assays to confirm Nrf2's role in promoting SOX9 transcription.
- Findings indicate that loss of Nrf2 leads to decreased SOX9 and increased cartilage degeneration, suggesting that enhancing Nrf2 activity could be a therapeutic strategy to alleviate age-related cartilage issues.
Glutamatergic transmission converging on calcium signaling plays a key role in dendritic differentiation. In early development, AMPA receptor (AMPAR) transcripts are extensively spliced and edited to generate subunits that differ in their biophysical properties. Whether these subunits have specific roles in the context of structural differentiation is unclear.
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