Publications by authors named "Claudius Boehm"
Article Synopsis
- Human relaxin-2 is a hormone important for mediating blood flow changes during pregnancy and has potential benefits in treating acute heart failure, but its clinical use is limited due to a short half-life and requirement for intravenous administration.
- Researchers developed long-acting relaxin peptide mimetics by modifying the B-chain of relaxin, leading to simpler and more potent peptide agonists for the relaxin receptor RXFP1.
- These new lipidated peptide agonists demonstrated high activity, better bioavailability when taken subcutaneously, and longer half-lives, making them promising candidates for wider therapeutic use.
