Publications by authors named "Claudio Sierra Gonzalez"
Article Synopsis
- Podocytes are essential for kidney function, adapting to inflammation while maintaining their structure, particularly during glomerulonephritis (GN).
- Research using wild-type and podocyte-specific MyD88 knockout mice in nephrotoxic nephritis (NTN) showed that MYD88 is important for initiating inflammatory responses, but its absence didn't significantly change podocyte behavior during inflammation.
- Next-generation sequencing revealed that while inflammation affects podocyte gene expression, some responses occur through other pathways, indicating that MYD88-independent mechanisms also play a role in podocyte adaptation.
Significance Statement: Treatment of acute, crescentic glomerulonephritis (GN) consists of unspecific and potentially toxic immunosuppression. T cells are central in the pathogenesis of GN, and various checkpoint molecules control their activation. The immune checkpoint molecule B and T-lymphocyte attenuator (BTLA) has shown potential for restraining inflammation in other T-cell-mediated disease models.
View Article and Find Full Text PDF