Publications by authors named "Claudio R Bilder"
Previous studies showed that circulating autoantibodies against M muscarinic receptors (anti-MR Ab) are associated with decreased cardiac parasympathetic modulation in patients with chronic Chagas disease (CD). Here we investigated whether the exposure of MR to such antibodies could impair agonist-induced receptor activation, leading to the inhibition of associated signaling pathways. Preincubation of MR-expressing HEK 293T cells with serum IgG fractions from chagasic patients with cardiovascular dysautonomia, followed by the addition of carbachol, resulted in the attenuation of agonist-induced G protein activation and arrestin-2 recruitment.
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- The study focused on comparing the enteric nervous systems in patients with chagas disease-related megacolon, idiopathic megacolon, and a control group.
- A total of 12 chagasic megacolon patients, 9 idiopathic megacolon patients, and 10 control patients were examined through surgical specimens for differences in nerve and cell types.
- Findings revealed significant reductions in enteric neurons and glial cells in chagasic patients, along with increased fibrosis and mild lymphocyte infiltration, indicating notable abnormalities in their enteric nervous systems compared to both idiopathic and control patients.