Publications by authors named "Claudio H Pech-Cervantes"
Deep DNA sequencing of MGMT, TP53 and AGT in Mexican astrocytoma patients identifies an excess of genetic variants in women and a predictive biomarker.
José Alberto Carlos-Escalante Sonia Iliana Mejía-Pérez Ernesto Soto-Reyes Lissania Guerra-Calderas Bernardo Cacho-Díaz Claudio Hiram Pech-Cervantes
J Neurooncol
January 2023
Article Synopsis
- Astrocytomas are aggressive brain tumors, and this study explores the role of specific genetic variants (AGT, MGMT, TP53) in their prognosis, particularly in Mexican patients.
- Researchers sequenced DNA from 48 Mexican patients with astrocytoma to identify variants and compared the results to a larger dataset from The Cancer Genome Atlas.
- Findings revealed more AGT and MGMT variants in the Mexican cohort, with AGT variants only found in women, and both MGMT variations and promoter methylation linked to improved survival and chemotherapy response, suggesting distinct molecular profiles based on gender and population.
Introduction: Diffuse gliomas are brain neoplasms with an infiltrative growing pattern to cortical and subcortical structures, frequently adjacent to eloquent areas; direct cortical and subcortical stimulation in awake craniotomy is a useful tool to achieve a gross total resection with the least neurological deficit.
Presentation Of Cases: A 24 years old male presented with tonic-clonic seizures. The magnetic resonance imaging (MRI) showed a left parietal glioma.