Low-molecular-weight dextran sulfate prevents experimental urolithiasis in rats.

Background: Low-molecular-weight dextran sulfate was tested on an experimental model of urolithiasis induced in rats.

Methods: Male Wistar rats weighing 250 g had a 15-mg calcium oxalate stone surgically placed into the bladder. A group was sham operated, another group was treated by daily intraperitoneal injection of low-molecular-weight dextran sulfate and the other by daily intraperitoneal saline injection.