Mobile Experience Sampling (MES) is a promising tool for understanding youth digital media use and its effects. Unfortunately, the method suffers from high levels of missing data. Depending on whether the data is randomly or non-randomly missing, it can have severe effects on the validity of findings.
View Article and Find Full Text PDFScientists increasingly use Twitter for communication about science. The microblogging service has been heralded for its potential to foster public engagement with science; thus, measuring how engaging, that is dialogue-oriented, tweet content is, has become a relevant research object. Tweet content designed in an engaging, dialogue-oriented way is also supposed to link to user interaction (e.
View Article and Find Full Text PDF(+)-Norfenfluramine, the major metabolite of fenfluramine, causes vasoconstriction dependence on the 5-hydroxytryptamine (5-HT)(2A) receptor in rat. (+)-Norfenfluramine was reported as a 5-hydroxytryptamine transporter (5-HTT) substrate and 5-HT releaser. Because the arterial 5-HTT exists and is functional in the rat, we hypothesized that (+)-norfenfluramine causes vasoconstriction by releasing 5-HT from vascular smooth muscle via 5-HTT.
View Article and Find Full Text PDFSerotonin is a neurotransmitter in the central nervous system. In the periphery, serotonin functions as a ubiquitous hormone involved in vasoconstriction and platelet function. Serotonin is synthesized independently in peripheral tissues and neurons by two different rate-limiting tryptophan hydroxylase (TPH) isoenzymes.
View Article and Find Full Text PDF