Publications by authors named "Claudia Silver"
Purpose: To determine comprehensive treatment parameters predictive of complete pathologic necrosis (CPN) in early-stage hepatocellular carcinoma (HCC) treated with glass microsphere radiation segmentectomy (RS).
Methods: This study is a secondary analysis of 61 tumors with available post-treatment imaging from a previously published cohort treated with RS using Yttrium-90-containing glass microspheres prior to liver transplantation. Post-treatment Bremsstrahlung SPECT-CT single-compartment, multi-compartment, and voxel-based dosimetry analyses were performed using dose confirmation software and compared between tumors that achieved CPN vs.
Article Synopsis
- The study investigates the health, metabolic, and behavioral impacts of perinatal cannabidiol (CBD) exposure on female mice and their offspring into adulthood, highlighting the lack of research on this widely used supplement.
- Results indicate that maternal CBD exposure can negatively affect offspring survival and postnatal development, particularly in males, while also producing various sex-dependent metabolic and behavioral changes in adults.
- The findings suggest CBD exposure during pregnancy and lactation influences behaviors such as anxiety and obsessive-compulsive traits, with significant implications for understanding the safety and effects of CBD use during pregnancy.
Article Synopsis
- Unresectable hepatocellular carcinoma (HCC) has a poor outlook when it doesn't respond to first-line immunotherapy, and second-line treatments like tyrosine kinase inhibitors only offer modest improvements.
- The effectiveness of combining local therapies, such as immunotherapy rechallenge, remains unclear for these patients, but radioembolization has shown promise when paired with immunotherapy.
- A reported case details a patient with aggressive HCC who, after failing previous treatments, achieved a complete pathologic response and is over two years without recurrence after receiving a combination of ipilimumab, nivolumab, and radioembolization.
Rationale: The behavioral effects of cannabidiol (CBD) are understudied, but are important, given its therapeutic potential and widespread use as a natural supplement.
Objective: The objective of this study was to test whether a single injection of CBD affected anxiety-like or attention-like behavior, or memory in wildtype mice or mice with reported trait anxiety due to a targeted gene-deletion in a voltage-dependent potassium channel, Kv1.3.