Cytotoxicity of Extracts from Leaves on Yeast.

L. is a plant used in traditional medicine harboring pharmacological properties with anti-inflammatory, antinociceptive, hypoglycemiant and anesthetic activities. This study assessed the potential cytotoxic, genotoxic and mutagenic effects of ethanolic extract of on strains.

Burnout in the Pharmaceutical Activity: The Impact of COVID-19.

Importance: Pharmacists are among the healthcare professionals involved in the response to the COVID-19 pandemic, maintaining essential services. In the context of restrictions and reorganization of human resources, as a result of policies recently applied to the health sector, following international guidelines, and given the scarcity of data on burnout in pharmaceutical activity, it was considered highly relevant to promote a nationwide survey aiming to collect more complete evidence on the burnout syndrome and to understand how pharmacists have viewed their work and the people they worked closely with.

Objectives: The study aimed to assess the occurrence of pharmacist burnout and determine outcomes for each of its dimensions; identify potentially associated characteristics; and determine profiles and critical limits.

Nuclear and mitochondrial genome instability induced by fractions of ethanolic extract from Hovenia dulcis Thunberg in Saccharomyces cerevisiae strains.

Hovenia dulcis is a plant commonly used as a pharmaceutical supplement, having displayed important pharmacological properties such antigiardic, antineoplastic and hepatoprotective. The purpose of this work was investigate the cytotoxic, genotoxic and mutagenic potential from fractions of Hovenia dulcis ethanolic extract on Saccharomyces cerevisiae strains FF18733 (wild type) and CD138 (ogg1). Ethanolic extract from Hovenia dulcis leaves was fractioned using organic solvents according to increasing polarity: Hexane (1:1), dichlorometane (1:1), ethyl acetate (1:1) and butanol (1:1).

Predation of a squirrel monkey (Saimiri sciureus) by an Amazon tree boa (Corallus hortulanus): even small boids may be a potential threat to small-bodied platyrrhines.

Predation has been suggested to play a major role in the evolution of primate ecology, although reports of predation events are very rare. Mammalian carnivores, raptors, and snakes are known predators of Neotropical primates, and most reported attacks by snakes are attributed to Boa constrictor (terrestrial boas). Here, we document the predation of a squirrel monkey (Saimiri sciureus) by an Amazon tree boa (Corallus hortulanus), the first record of the predation of a platyrrhine primate by this boid.

Diversity and Karyotypic Evolution in the Genus Neacomys (Rodentia, Sigmodontinae).

Neacomys (Sigmodontinae) comprises 8 species mainly found in the Amazonian region. We describe 5 new karyotypes from Brazilian Amazonia: 2 cytotypes for N. paracou (2n = 56/FNa = 62-66), 1 for N.

Influence of Ogg1 repair on the genetic stability of ccc2 mutant of Saccharomyces cerevisiae chemically challenged with 4-nitroquinoline-1-oxide (4-NQO).

In Saccharomyces cerevisiae, disruption of genes by deletion allowed elucidation of the molecular mechanisms of a series of human diseases, such as in Wilson disease (WD). WD is a disorder of copper metabolism, due to inherited mutations in human copper-transporting ATPase (ATP7B). An orthologous gene is present in S.

Low back pain disability and stay at work: contradiction or necessity?

The incidence of occupational diseases in the population is high and factors such as long working hours, poor posture, psychological and physical stress can contribute to its development. Among work-related musculoskeletal disorders, back pain has a high prevalence. The aim of the present study was to quantify and characterize pain complaints and to identify individuals with low back pain, in order to assess the degree of disability.

Concepts of health in nursing education in undergraduate schools of Brazil and portugal.

This article represents an extract of my PhD research regarding the concepts of health present in undergraduate schools of nursing of Brazil and Portugal. The objective of this research was to comprehend how the concepts of health are explicit in the documents of undergraduate courses and how they are expressed in the discourses of the nursing professors and students. For this, thematic content analysis was used to analyze the professional education of the nurses and the concepts of health present in the nursing courses.

Genotoxic and Cytotoxic Safety Evaluation of Papain (Carica papaya L.) Using In Vitro Assays.

Papain, a phytotherapeutic agent, has been used in the treatment of eschars and as a debriding chemical agent to remove damaged or necrotic tissue of pressure ulcers and gangrene. Its benefits in these treatments are deemed effective, since more than 5000 patients, at the public university hospital at Rio de Janeiro, Brazil, have undergone papain treatment and presented satisfactory results. Despite its extensive use, there is little information about toxic and mutagenic properties of papain.

[Interdisciplinary education for health: planning nurse undergraduate programs].

Interdisciplinary teaching as an educational alternative which allows for global education of individuals who are also professionals is shown in this article as an educational planning report organized by the undergraduate Nursing program from Regional University of Blumenau (FURB), located in the city of Blumenau, in the state of Santa Catarina, Brazil. We show this didactic-pedagogical perspective from a theoretical perspective that presents ethics as an alternative for an education process aimed at the global community. This is a didactic proceeding supported by the methodology of "culture circles", proposed by Paulo Freire.

Radiation induced-like effects of four home bleaching agents used for tooth whitening: effects on bacterial cultures with different capabilities of repairing deoxyribonucleic acid (DNA) damage.

"Home bleaching" methods are commonly used in dentistry to correct tooth discoloration. This technique employs carbamide peroxide, in several concentrations, where the active component is hydrogen peroxide. In patients undertaking this treatment, this exposure can cause biological effects mainly due to the activity of hydrogen peroxide.

Biological effects of rutin on the survival of Escherichia coli AB1157 and on the electrophoretic mobility of plasmid PUC 9.1 DNA.

The use of natural products as medicines is growing in the world. The rutin, a compound isolated from Ruta graveolens, is a flavonoid, which has been suggested to have antioxidant properties and to reduce the triacylglycerol levels. In this study, plasmid desoxyribonucleic acid (DNA) was exposed to rutin (0.